Evidence map›Paper›PMID 37310308›Full record

Trial reportPsychological medicine2023

Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial.

Mark A Straccia, Adam R Teed, Perri L Katzman, Kevin M Tan, Michael H Parrish, Michael R Irwin, Naomi I Eisenberger, Matthew D Lieberman, Benjamin A Tabak

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02393443 early_phase1completednot on this map

The Effects of Oxytocin on Learning With Social Versus Nonsocial Motivation

TypeinterventionalSponsorUniversity of California, Los AngelesRan2015 to 2016Enrolled161ConditionsSocial PsychologyArmsIntranasal oxytocin, Intranasal placebo
NCT02393456 early_phase1completednot on this map

Oxytocin's Effects on Behavior and Neural Activity During Social Cognition Tasks

TypeinterventionalSponsorUniversity of California, Los AngelesRan2015 to 2016Enrolled161ConditionsSocial PsychologyArmsIntranasal oxytocin, Intranasal placebo
NCT02394054 early_phase1completednot on this map

Vasopressin's Effect on Behavior and Neural Activity During Social Cognition Tasks

TypeinterventionalSponsorUniversity of California, Los AngelesRan2015 to 2016Enrolled84ConditionsSocial PsychologyArmsIntranasal vasopressin, Intranasal placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Hormonal abnormalities in alexithymia.Frontiers in psychiatry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark A StracciaDepartment of Psychology, University of California, Los Angeles, CA, USA.
Adam R TeedDepartment of Psychology, Southern Methodist University, Dallas, TX, USA.
Perri L KatzmanDepartment of Psychology, New York University, New York, NY, USA.
Kevin M TanDepartment of Psychology, University of California, Los Angeles, CA, USA.
Michael H ParrishDepartment of Psychology, University of California, Los Angeles, CA, USA.
Michael R IrwinDepartment of Psychology, University of California, Los Angeles, CA, USA.
Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, CA, USA.
Matthew D LiebermanDepartment of Psychology, University of California, Los Angeles, CA, USA.
Benjamin A TabakDepartment of Psychology, Southern Methodist University, Dallas, TX, USA.ORCID 0000-0003-0833-5705

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

backgroundAlthough potential links between oxytocin (OT), vasopressin (AVP), and social cognition are well-grounded theoretically, most studies have included all male samples, and few have demonstrated consistent effects of either neuropeptide on mentalizing (i.e. understanding the mental states of others). To understand the potential of either neuropeptide as a pharmacological treatment for individuals with impairments in social cognition, it is important to demonstrate the beneficial effects of OT and AVP on mentalizing in healthy individuals.

methodsIn the present randomized, double-blind, placebo-controlled study (

resultsRelative to placebo, neither drug showed an effect on task reaction time or accuracy, nor on whole-brain neural activation or functional connectivity observed within brain networks associated with mentalizing. Exploratory analyses included several variables previously shown to moderate OT's effects on social processes (e.g., self-reported empathy, alexithymia) but resulted in no significant interaction effects.

conclusionsResults add to a growing literature demonstrating that intranasal administration of OT and AVP may have a more limited effect on social cognition, at both the behavioral and neural level, than initially assumed. Randomized controlled trial registrations: ClinicalTrials.gov; NCT02393443; NCT02393456; NCT02394054.

Indexed as

MentalizationOxytocinVasopressinsAdministration, IntranasalHealthy VolunteersHumansMagnetic Resonance ImagingNegative ResultsOxytocinVasopressinsfMRIfunctional connectivitymentalizingoxytocintheory of mindvasopressin

Identifiers

PMID37310308
PMCPMC10123837

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.