ArticlePsychological medicine2023
Shared genetic and environmental etiology between substance use disorders and suicidal behavior.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Lifetime substance use disorder and suicidal behaviour: a population-based familial co-aggregation register study.Molecular psychiatry · 2026Article
- The impact of alcohol use disorder and PTSD comorbidity on risk of suicide attempt.Social psychiatry and psychiatric epidemiology · 2026Article
- Elucidating psychosocial outcome profiles as a function of aggregate genetic risk for suicide attempt and alcohol use disorder.Translational psychiatry · 2026Article
- High Prevalence of Suicidal Behavior in Severe Alcohol Use Disorder Linked to Specific Neurocognitive Deficits: The Cognition, Alcohol, Genes, and Environment Study.Journal of studies on alcohol and drugs · 2026Article
- Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence.Translational psychiatry · 2026Article
- Method-specific suicide mortality rates among older adults in 47 countries and territories, 1996-2021, with projections to 2050: a global time series and modelling study.The lancet. Healthy longevity · 2025Article
- Mediational pathways between aggregate genetic liability and nonfatal suicide attempt: A Swedish population-based cohort.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Alcohol use disorder and risk of specific methods of suicide death in a national cohort.Acta psychiatrica Scandinavica · 2024Article
- Risk of suicidal behavior as a function of alcohol use disorder typologies: A Swedish population-based study.Addiction (Abingdon, England) · 2024Article
- The role of substance use disorders in the transition from suicide attempt to suicide death: a record linkage study of a Swedish cohort.Psychological medicine · 2024Article
- Shared genetic liability for alcohol consumption, alcohol problems, and suicide attempt: Evaluating the role of impulsivity.Translational psychiatry · 2023Article
- Examining common and distinct contributions to the etiology of suicide attempt and reattempt.Journal of psychopathology and clinical science · 2023Article
- Genetic differences between suicide deaths and deaths of undetermined intent.Suicide & life-threatening behavior · 2023Article
- Sibling alcohol use disorder is associated with increased risk for suicide attempt.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies have demonstrated substantial associations between substance use disorders (SUD) and suicidal behavior. The current study empirically assesses the extent to which shared genetic and/or environmental factors contribute to associations between alcohol use disorders (AUD) or drug use disorders (DUD) and suicidal behavior, including attempts and death.
methodsThe authors used Swedish national registry data, including medical, pharmacy, criminal, and death registrations, for a large cohort of twins, full siblings, and half siblings (
resultsGenetic correlations between SA and SUD ranged from rA = 0.60-0.88; corresponding shared environmental correlations were rC = 0.42-0.89 but accounted for little overall variance; and unique environmental correlations were rE = 0.42-0.57. When replacing attempt with SD, genetic and shared environmental correlations with AUD and DUD were comparable (rA = 0.48-0.72, rC = 0.92-1.00), but were attenuated for unique environmental factors (rE = -0.01 to 0.31).
conclusionsThese findings indicate that shared genetic and unique environmental factors contribute to comorbidity of suicidal behavior and SUD, in conjunction with previously reported causal associations. Thus, each outcome should be considered an indicator of risk for the others. Opportunities for joint prevention and intervention, while limited by the polygenic nature of these outcomes, may be feasible considering moderate environmental correlations between SA and SUD.
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