Evidence map›Paper›PMID 37310228›Full record

ArticleJournal of virology2023

Neuroinvasive Flavivirus Pathogenesis Is Restricted by Host Genetic Factors in Collaborative Cross Mice, Independently of

Brittany A Jasperse, Melissa D Mattocks, Kelsey E Noll, Martin T Ferris, Mark T Heise, Helen M Lazear

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. DifferentiatingInfection and immunity · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brittany A Jasperse *Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-9141-3246
Melissa D Mattocks *Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-8317-5284
Kelsey E NollDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3977-0083
Martin T FerrisDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Mark T HeiseDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-5829-8477
Helen M LazearDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8649-4579
University of North Carolina at Chapel Hill · US

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 2012 to 2021
$36.6M
Molecular Biology of Viral Diseases Predoctoral Training GrantT32AI007419 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark T Heise, CARY A MOODY · 1993 to 2026
$4.7M
Host Factors Controlling Neuroinvasive Flavivirus PathogenesisR01AI170625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2022 to 2025
$1.6M
Identifying Novel Immune Factors Controlling Flavivirus PathogenesisR21AI145377 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2019 to 2020
$427k
Host genetic determinants of neuroinvasive flavivirus pathogenesisF32AI161786 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERSE, BRITTANY · 2022 to 2023
$87k
NIAID NIH HHS F32 AI161786NIAID NIH HHS R01 AI170625NIAID NIH HHS R21 AI145377NIAID NIH HHS T32 AI007419NIAID NIH HHS U19 AI100625
6 · The paper itself

Abstract

Powassan virus (POWV) is an emerging tick-borne flavivirus that causes neuroinvasive diseases, including encephalitis, meningitis, and paralysis. Similar to other neuroinvasive flaviviruses, such as West Nile virus (WNV) and Japanese encephalitis virus (JEV), POWV disease presentation is heterogeneous, and the factors influencing disease outcome are not fully understood. We used Collaborative Cross (CC) mice to assess the impact of host genetic factors on POWV pathogenesis. We infected a panel of

Indexed as

EncephalitisEncephalitis Viruses, Tick-BorneEncephalitis Virus, JapaneseFlavivirusFlavivirus InfectionsWest Nile virus2',5'-Oligoadenylate SynthetaseAnimalsCollaborative Cross MiceDisease SusceptibilityHumansMiceParalysis2',5'-Oligoadenylate SynthetaseOas1b protein, mouseCollaborative Cross miceneuroinvasive flavivirusesPowassan virus

Identifiers

PMID37310228
PMCPMC10373552
OpenAlexW4380422530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.