Evidence map›Paper›PMID 37309907›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2023

Economic impact of reducing treatment gaps in depression.

Paul McCrone, Allan H Young, Roland Zahn, Jonas Eberhard, Danuta Wasserman, Paolo Brambilla, Judit Balazs, Jose Caldas-de-Almeida, Andrea Ulrichsen, Vladmir Carli and 5 more

Abstract read
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. The European Brain Council Value of Treatment studies in depression and autism.European psychiatry : the journal of the Association of European Psychiatrists · 2023
    Article
  4. Care pathways for people with major depressive disorder: a European Brain Council Value of Treatment study.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paul McCroneInstitute for Lifecourse Development, University of Greenwich, London, UK.ORCID 0000-0001-7001-4502
Allan H YoungDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-2291-6952
Roland ZahnDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-8447-1453
Jonas EberhardDivision of Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden.ORCID 0000-0003-0364-2626
Danuta WassermanNational Centre for Suicide Research and Prevention of Mental Ill-Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8436-3989
Paolo BrambillaDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-4021-8456
Judit BalazsDepartment of Developmental & Clinical Child Psychology, Institute of Psychology, Eötvös Loránd University, Budapest, Hungary.ORCID 0000-0001-6397-1419
Jose Caldas-de-AlmeidaChronic Diseases Research Center, Nova Medical School, Nova University of Lisbon, Lisbon, Portugal.ORCID 0000-0003-1902-6772
Andrea UlrichsenDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-3522-0620
Vladmir CarliNational Centre for Suicide Research and Prevention of Mental Ill-Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6922-0675
Ana AntunesChronic Diseases Research Center, Nova Medical School, Nova University of Lisbon, Lisbon, Portugal.ORCID 0000-0002-1280-6672
Giandomenico SchienaDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0001-5589-8071
Vinciane QuoidbachEuropean Brain Council, Brussels, Belgium.ORCID 0000-0002-4554-6432
Patrice BoyerEuropean Brain Council, Brussels, Belgium.
Rebecca StrawbridgeDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Funding

Department of Health
6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) is highly prevalent across Europe. While evidence-based treatments exist, many people with MDD have their condition undetected and/or untreated. This study aimed to assess the cost-effectiveness of reducing treatment gaps using a modeling approach.

methodsA decision-tree model covering a 27-month time horizon was used. This followed a care pathway where MDD could be detected or not, and where different forms of treatment could be provided. Expected costs pertaining to Germany, Hungary, Italy, Portugal, Sweden, and the UK were calculated and quality-adjusted life years (QALYs) were estimated. The incremental costs per QALY of reducing detection and treatment gaps were estimated.

resultsThe expected costs with a detection gap of 69% and treatment gap of 50% were €1236 in Germany, €476 in Hungary, €1413 in Italy, €938 in Portugal, €2093 in Sweden, and €1496 in the UK. The incremental costs per QALY of reducing the detection gap to 50% ranged from €2429 in Hungary to €10,686 in Sweden. The figures for reducing the treatment gap to 25% ranged from €3146 in Hungary to €13,843 in Sweden.

conclusionsReducing detection and treatment gaps, and maintaining current patterns of care, is likely to increase healthcare costs in the short term. However, outcomes are improved, and reducing these gaps to 50 and 25%, respectively, appears to be a cost-effective use of resources.

Indexed as

Major Depressive DisorderCost-Benefit AnalysisDepressionEuropeHealth Care CostsHumansItalycostdepressioneconomicsgapstreatment

Identifiers

PMID37309907
PMCPMC10486252

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.