ArticleEuropean heart journal. Cardiovascular Imaging2023
Characterizing the hypertensive cardiovascular phenotype in the UK Biobank.
Article in European heart journal. Cardiovascular Imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Contrastive Machine Learning to Quantify Hypertensive Multiorgan Damage and Identify New Disease Phenotypes: A Multinational Multimodal Study.Circulation · 2026Article
- Article
- Clinical Phenotypes in Hypertension: A Data-Driven Approach to Risk Stratification.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy.BMC medicine · 2026Article
- Chronotype, Life's Essential 8, and Risk of Cardiovascular Disease: A Prospective Cohort Study in UK Biobank.Journal of the American Heart Association · 2026Article
- Limited transferability of European-based body mass index and blood pressure polygenic scores to admixed Brazilian cohorts.Frontiers in medicine · 2026Article
- Cardiac magnetic resonance characteristics and prognostic associations of hypertension-mediated left ventricular hypertrophy.European heart journal. Imaging methods and practice · 2026Article
- Causal relevance of clonal haematopoiesis with cardiac disease and adverse remodelling: a Mendelian randomisation study.Open heart · 2025Article
- Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study.European journal of preventive cardiology · 2025Observational
- Loneliness, social isolation and stroke risk in men and women with and without diabetes.BMC public health · 2025Article
- Diabetes mellitus exacerbates cardiovascular remodeling in elderly Chinese by affecting aortic diameter and pulsatile load.Scientific reports · 2025Observational
- Ultra-stretchable, adhesive and photothermal multifunctional hydrogel for renal denervation to treat hypertension.Materials today. Bio · 2025Article
- Analysis of atrioventricular function and myocardial strain in hypertensive heart disease: a CMR-based study.Scientific reports · 2025Article
- Cardiovascular diseases in the elderly: possibilities for modulating autophagy using non-coding RNAs.Frontiers in cell and developmental biology · 2025Review
- Cardiac hypertrophy in polycythemia vera: A case report and review of literature.World journal of cardiology · 2024Article
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12 authors at 5 institutions in 2 countries.
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Abstract
aimsTo describe hypertension-related cardiovascular magnetic resonance (CMR) phenotypes in the UK Biobank considering variations across patient populations. METHODS AND
resultsWe studied 39 095 (51.5% women, mean age: 63.9 ± 7.7 years, 38.6% hypertensive) participants with CMR data available. Hypertension status was ascertained through health record linkage. Associations between hypertension and CMR metrics were estimated using multivariable linear regression adjusting for major vascular risk factors. Stratified analyses were performed by sex, ethnicity, time since hypertension diagnosis, and blood pressure (BP) control. Results are standardized beta coefficients, 95% confidence intervals, and P-values corrected for multiple testing. Hypertension was associated with concentric left ventricular (LV) hypertrophy (increased LV mass, wall thickness, concentricity index), poorer LV function (lower global function index, worse global longitudinal strain), larger left atrial (LA) volumes, lower LA ejection fraction, and lower aortic distensibility. Hypertension was linked to significantly lower myocardial native T1 and increased LV ejection fraction. Women had greater hypertension-related reduction in aortic compliance than men. The degree of hypertension-related LV hypertrophy was greatest in Black ethnicities. Increasing time since diagnosis of hypertension was linked to adverse remodelling. Hypertension-related remodelling was substantially attenuated in hypertensives with good BP control.
conclusionHypertension was associated with concentric LV hypertrophy, reduced LV function, dilated poorer functioning LA, and reduced aortic compliance. Whilst the overall pattern of remodelling was consistent across populations, women had greater hypertension-related reduction in aortic compliance and Black ethnicities showed the greatest LV mass increase. Importantly, adverse cardiovascular remodelling was markedly attenuated in hypertensives with good BP control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.