Evidence map›Paper›PMID 37309730›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2023

Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum.

Brier Fine-Raquet, Francesca M Manzella, Srdjan M Joksimovic, Robert M Dietz, James E Orfila, Dayalan Sampath, Vesna Tesic, Navya Atluri, Douglas F Covey, Yogendra H Raol and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Brier Fine-RaquetDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Francesca M ManzellaDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Srdjan M JoksimovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Robert M DietzDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
James E OrfilaDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Dayalan SampathDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University, College Station, TX 77843, USA.
Vesna TesicDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA.
Navya AtluriDepartment of Anesthesiology, University of Virginia, Charlottesville, VA 22903, USA.
Douglas F CoveyDepartment of Developmental Biology, St. Louis School of Medicine, Washington University, St. Louis, MO 63130, USA.
Yogendra H RaolDepartment of Pediatrics, Division of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Vesna Jevtovic-TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Paco S HersonDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Slobodan M TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-2613-0391
University of Colorado Anschutz Medical Campus · USLouisiana State University Health Sciences Center Shreveport · USNational Institutes of Health · USTexas A&M University · USUniversity of Virginia · USWashington University in St. Louis · US

Funding

Voltage-gated calcium channels as target for anestheticsR35GM141802 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Slobodan M. Todorovic · 2021 to 2026
$3.1M
Anesthesia-induced developmental neurodegenerationR01HD044517 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI JEVTOVIC-TODOROVIC, VESNA · 2005 to 2014
$3.0M
Novel neurosteroid anesthetics and developmental synaptogenesisR01HD097990 · NICHD · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2019 to 2023
$2.9M
In vivo imaging of thalamocortical excitability during anesthesiaR01GM102525 · NIGMS · UNIVERSITY OF VIRGINIA · PI TODOROVIC, SLOBODAN M. · 2014 to 2020
$2.0M
FVMPE-RS Riser System for in vivo and in vitro imaging on anesthesia-induced developmental neurotoxicityR01GM118197 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2016 to 2019
$1.7M
Anesthesia impairs developmental axon pruning and functional neuronal networksR21HD080281 · NICHD · UNIVERSITY OF VIRGINIA · PI JEVTOVIC-TODOROVIC, VESNA · 2015 to 2016
$428k
Neonatal anesthesia-induced delay of axon pruning in hippocampusF32HD101357 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CABRERA, OMAR HOSEA · 2020 to 2020
$67k
NICHD NIH HHS F32 HD101357NICHD NIH HHS R01 HD044517NICHD NIH HHS R01 HD097990NICHD NIH HHS R21 HD080281NIGMS NIH HHS R01 GM102525NIGMS NIH HHS R01 GM118197NIGMS NIH HHS R35 GM141802
6 · The paper itself

Abstract

Preclinical studies have established that neonatal exposure to contemporary sedative/hypnotic drugs causes neurotoxicity in the developing rodent and primate brains. Our group recently reported that novel neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) induced effective hypnosis in both neonatal and adult rodents but did not cause significant neurotoxicity in vulnerable brain regions such as subiculum, an output region of hippocampal formation particularly sensitive to commonly used sedatives/hypnotics. Despite significant emphasis on patho-morphological changes, little is known about long-term effects on subicular neurophysiology after neonatal exposure to neuroactive steroids. Hence, we explored the lasting effects of neonatal exposure to 3β-OH on sleep macrostructure as well as subicular neuronal oscillations

Indexed as

NeurosteroidsAnimalsHippocampusHypnotics and SedativesNeuronal PlasticityRatsRats, Sprague-DawleyHypnotics and SedativesNeurosteroids3β-OHbrain developmentEEGhypnosislong-term potentiation

Identifiers

PMID37309730
PMCPMC10350800
OpenAlexW4380421916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.