Evidence map›Paper›PMID 37309679›Full record

SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Risk of Tuberculosis Disease in People With Chronic Kidney Disease Without Kidney Failure: A Systematic Review and Meta-analysis.

Pauline Luczynski, Thomas Holmes, Kamila Romanowski, Omri A Arbiv, Victoria J Cook, Edward G Clark, James C Johnston

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Pauline LuczynskiDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Thomas HolmesSchool of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Kamila RomanowskiDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Omri A ArbivDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Victoria J CookDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Edward G ClarkDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
James C JohnstonDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CABC Centre for Disease Control · CARoyal College of Surgeons in Ireland · IEUniversity of Ottawa · CA

Funding

CIHR PJT- 153213
6 · The paper itself

Abstract

backgroundKidney failure is an established risk factor for tuberculosis (TB), but little is known about TB risk in people with chronic kidney disease (CKD) who have not initiated kidney replacement therapy (CKD without kidney failure). Our primary objective was to estimate the pooled relative risk of TB disease in people with CKD stages 3-5 without kidney failure compared with people without CKD. Our secondary objectives were to estimate the pooled relative risk of TB disease for all stages of CKD without kidney failure (stages 1-5) and by each CKD stage.

methodsThis review was prospectively registered (PROSPERO CRD42022342499). We systematically searched MEDLINE, Embase, and Cochrane databases for studies published between 1970 and 2022. We included original observational research estimating TB risk among people with CKD without kidney failure. Random-effects meta-analysis was performed to obtain the pooled relative risk.

resultsOf the 6915 unique articles identified, data from 5 studies were included. The estimated pooled risk of TB was 57% higher in people with CKD stages 3-5 than in people without CKD (adjusted hazard ratio: 1.57; 95% CI: 1.22-2.03; I2 = 88%). When stratified by CKD stage, the pooled rate of TB was highest in stages 4-5 (incidence rate ratio: 3.63; 95% CI: 2.25-5.86; I2 = 89%).

conclusionsPeople with CKD without kidney failure have an increased relative risk of TB. Further research and modeling are required to understand the risks, benefits, and CKD cutoffs for screening people for TB with CKD prior to kidney replacement therapy.

Indexed as

Kidney Failure, ChronicRenal Insufficiency, ChronicTuberculosisHumansRenal Replacement TherapyRisk Factorschronic kidney diseaselatent tuberculosispre-dialysisrisk factortuberculosis

Identifiers

PMID37309679
PMCPMC10573716
OpenAlexW4380422224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.