Evidence map›Paper›PMID 37309454›Full record

ArticleIJID regions2023

Antibody responses to mRNA versus non-mRNA COVID vaccines among the Mongolian population.

Enkhbold Sereejav, Ankhbayar Sandagdorj, Purevbat Bazarjav, Sarangua Ganbold, Altansukh Enkhtuvshin, Naranzul Tsedenbal, Bayasgalan Namuuntsetseg, Khishigmunkh Chimedregzen, Darmaa Badarch, Dashpagma Otgonbayar and 11 more

Open access · goldAbstract read
In one paragraph

Article in IJID regions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 3 countries.

Enkhbold SereejavMinistry of Health, Ulaanbaatar, Mongolia.
Ankhbayar SandagdorjNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Purevbat BazarjavNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Sarangua GanboldNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Altansukh EnkhtuvshinNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Naranzul TsedenbalNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Bayasgalan NamuuntsetsegNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Khishigmunkh ChimedregzenNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Darmaa BadarchNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Dashpagma OtgonbayarNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Bayarzaya ArtbazarWorld Health Organization, Ulaanbaatar, Mongolia.
Oyunsuren EnebishMinistry of Health, Ulaanbaatar, Mongolia.
Erdembileg TsevegmidMinistry of Health, Ulaanbaatar, Mongolia.
Huricha BaigudeInner Mongolia University, Hohhot, China.
Uyanga BatzorigUniversity of California, San Diego, California, USA.
Bumdelger BatmunkhNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Baigalmaa JantsansengeeNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Chinbayar TserendorjNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Bayarsaikhan DorjderemNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Bilegtsaikhan TsolmonNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Tsogzolmaa GanboldNational Center for Communicable Diseases, Ulaanbaatar, Mongolia.
National Center for Communicable Diseases · MNMinistry of Health · MNInner Mongolia University · CNUniversity of California San Diego · US

Funding

World Health Organization 001
6 · The paper itself

Abstract

Background: A nationwide vaccination program against coronavirus disease 2019 (COVID-19) was started in Mongolia 4 months after the first local transmission, which occurred in November 2020. Previous studies have reported that two doses of COVID-19 vaccine result in increased antibody against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A study was conducted in Mongolia 2 weeks after the second vaccine dose. In the present study, the serum levels of antibodies of individuals 6 months after natural SARS-CoV-2 infection were compared with those of individuals who had not been infected or had been infected but had received two doses of vaccine, including BNT162b2, ChAdOx1 n-CoV-19, Gam-COVID-Vac, and BBIBP-CorV, which were used for COVID-19 in Mongolia. Methods: Of the 450 participants in this study, 237 (52.66%) were female and 213 (47.33%) were male. Four hundred people with or without SARS-CoV-2 infection who received two doses of 4 different COVID-19 vaccine participated in the vaccine groups and vaccine plus SARS-CoV-2 infection groups (50 in each group) and 50 individuals previously infected with SARS-CoV-2 participated in the unvaccinated group. Total antibody against SARS-CoV-2 infection, anti-SARS-CoV-2 N and S protein human IgG, and antibody inhibiting RBD-ACE2 binding were tested. Results: In the BNT162b2 vaccine group, total antibody against SARS-CoV-2 remained constant until 6 months, while the other vaccine groups showed a significant decrease, as compared to the unvaccinated group. The level of anti-SARS-CoV-2 S-RBD protein IgG was significantly increased in the ChAdOx1 n-CoV-19, Gam-COVID-Vac, and BNT162b2 vaccines groups as compared to the unvaccinated group. Participants in the BNT162b2 vaccine group had higher ACE2 inhibition efficiency compared to the other vaccine groups as well as the unvaccinated group. Conclusions: The BNT162b2 vaccine showed the highest level of antibody against SARS-CoV-2, followed by the BBIBP-CorV, Gam-COVID-Vac, and ChAdOx1 n-CoV-19 vaccines. The level of antibodies was increased in people infected with SARS-CoV-2 after vaccination, as compared to uninfected but vaccinated individuals.

Indexed as

Antibody responseBinding inhibitionCOVID-19SeverityVaccine

Identifiers

PMID37309454
PMCPMC10183229
OpenAlexW4376608766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.