ReviewCureus2023
Life Expectancy and Mortality After Lower Extremity Amputation: Overview and Analysis of Literature.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The effectiveness of rigid versus non-rigid dressings in reducing surgical site infections following major lower limb amputations: a systematic review.Systematic reviews · 2026Pooled it
- Surgical Site Infections in Major Lower Limb Amputation (SIMBA): international multicentre study.BJS open · 2026Observational
- Independent Predictors of Major Limb Amputation: A Systematic Review and Meta-Analysis of Adjusted Risk Factors.Healthcare (Basel, Switzerland) · 2026Review
- Article
- Ultra-distal bypass remains a valuable option for tibial disease with tissue loss.Journal of vascular surgery cases and innovative techniques · 2026Article
- The Combined Use of Ozone and Negative Pressure Wound Therapy in the Management of Diabetes-Related Foot Disease: A Retrospective Exploratory Cohort Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Noncontrast magnetic resonance angiography outperforms digital subtraction angiography in detecting hibernating below-the-knee arteries and downgrades Transatlantic Inter-Society Consensus and Global Limb Anatomic Staging System scores in chronic limb-threatening ischemia patients.Journal of vascular surgery · 2026Observational
- Functional outcomes and mortality after multi-limb amputations following the 2023 Türkiye earthquake: a two-year follow-up study from a level I trauma center.Journal of orthopaedic surgery and research · 2025Article
- Non-Traumatic Lower-Limb Amputations: Outcome, Sex-Differences, Comorbidity Patterns and Temporal Trends from 2006 to 2022.Journal of clinical medicine · 2025Article
- Impact of Podiatric Surveillance on Amputation Rates in Patients with Diabetes and Chronic Kidney Disease.The international journal of lower extremity wounds · 2025Article
- The misleading terminology of minor amputation of the lower limb.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications.Clinical epidemiology · 2025Article
- Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms.bioRxiv : the preprint server for biology · 2024Article
- Mortality after major lower extremity amputation and association with index level: a cohort study based on 11,205 first-time amputations from nationwide Danish databases.Acta orthopaedica · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower limb amputation (LLA) is a major surgical procedure with a significant impact on quality of life and mortality rates as well. Previous studies have shown that mortality rates following LLA can range from 9-17% within 30 days in the UK. This study systematically evaluates and reviews the published literature on life expectancy, mortality, and survival rates following lower extremity amputation (LEA). We have conducted a comprehensive search on Medline, CINAHL, and Cochrane Central databases resulting in 87 full-text articles. After a thorough review, only 45 (52.9%) articles met the minimum inclusion criteria for the study. Our analysis indicated 30-day mortality rates following LEA ranged from 7.1% to 51.4%, with an average mortality rate of 16.45% (SD 14.35) per study. Furthermore, 30-day mortality rates following below-knee amputation (BKA) and above-knee amputation (AKA) were found to be between 6.2% to 51.4%, X= 17.16% ± 19.46 SD and 12.7 to 21.7%, X= 16.15% ± 4.17 SD, respectively. Our review provides a comprehensive insight into the life expectancy, mortality, and survival rates following LEA. These findings highlight the importance of considering various factors, including patient age, presence of comorbidities such as diabetes, heart failure, and renal failure, and lifestyle factors such as smoking, in determining prognosis following LLA. Further research is necessary to determine strategies for improving outcomes and reducing mortality in this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.