ArticleCNS neuroscience & therapeutics2023
Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- The efficacy and mechanisms of low-intensity transcranial ultrasound stimulation on pain: a systematic review of human and animal studies.The journal of headache and pain · 2025Pooled it
- Transcranial ultrasound stimulation parameters for neurological diseases: a systematic review.Frontiers in neurology · 2025Pooled it
- Transcranial Ultrasound Stimulation of Internal Globus Pallidus Region and Motor Cortex in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Trial
- Closed-Loop Neuromodulation for Brain Fatigue: From Real-Time Biomarkers to Adaptive Intervention.International journal of molecular sciences · 2026Review
- Neuromodulation techniques targeting neurotransmitter dysfunction: Innovation in treatments for Alzheimer's disease.Neural regeneration research · 2026Article
- [Research progress on the neuromodulation targets in stroke rehabilitation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Review
- Transcranial focused ultrasound stimulation enhances semantic memory by modulating brain morphology, neurochemistry and neural dynamics.Nature communications · 2026Article
- Modulation of Posterior Insula Selectively Enhances Nociceptive Sensory Gating in Humans.medRxiv : the preprint server for health sciences · 2026Article
- Unlocking a Novel Therapeutic Modality: Low-Intensity Transcranial Ultrasound as a Key to CNS Treatment - A Bibliometric and Systematic Review.Journal of central nervous system disease · 2026Review
- Ultrasound neuromodulation in brain disorders: from mechanotransduction mechanisms to clinical translation.Frontiers in neuroscience · 2026Review
- Transcranial Focused Ultrasound Enhances the Discriminative Power of Targeted Voluntary Motor Signals in Humans.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Parameter-Determined Effects: Advances in Transcranial Focused Ultrasound for Modulating Neural Excitation and Inhibition.Bioengineering (Basel, Switzerland) · 2025Review
- A panoramic review of transcranial focused ultrasound neuromodulation: from basic research to clinical applications.Journal of neuroengineering and rehabilitation · 2025Review
- Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.medRxiv : the preprint server for health sciences · 2025Article
- Transcranial Focused Ultrasound Modulates Feedforward and Feedback Cortico-Thalamo-Cortical Pathways by Selectively Activating Excitatory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential.CNS neuroscience & therapeutics · 2024Review
- Neuromodulatory Responses Elicited by Intermittent versus Continuous Transcranial Focused Ultrasound Stimulation of the Motor Cortex in Rats.International journal of molecular sciences · 2024Article
- Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain.Journal of anesthesia, analgesia and critical care · 2024Review
- A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound.Biomedical engineering letters · 2024Review
- Update on Non-invasive Brain Stimulation on Stroke Motor Impairment: A Narrative Review.Brain & NeuroRehabilitation · 2024Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsTranscranial focus ultrasound stimulation (tFUS) is a promising non-invasive neuromodulation technology. This study aimed to evaluate the modulatory effects of tFUS on human motor cortex (M1) excitability and explore the mechanism of neurotransmitter-related intracortical circuitry and plasticity.
methodsSingle pulse transcranial magnetic stimulation (TMS)-eliciting motor-evoked potentials (MEPs) were used to assessed M1 excitability in 10 subjects. Paired-pulse TMS was used to measure the effects of tFUS on GABA- and glutamate-related intracortical excitability and
resultsThe etFUS significantly increased M1 excitability, decreased short interval intracortical inhibition (SICI) and long interval intracortical inhibition (LICI). The itFUS significantly suppressed M1 excitability, increased SICI, LICI, and decreased intracortical facilitation (ICF). Seven times of etFUS decreased the GABA concentration (6.32%), increased the Glx concentration (12.40%), and decreased the GABA/Glx ratio measured by MRS, while itFUS increased the GABA concentration (18.59%), decreased Glx concentration (0.35%), and significantly increased GABA/Glx ratio.
conclusionThe findings support that tFUS with different parameters can exert excitatory and inhibitory neuromodulatory effects on the human motor cortex. We provide novel insights that tFUS change cortical excitability and plasticity by regulating excitatory-inhibition balance related to the GABAergic and glutamatergic receptor function and neurotransmitter metabolic level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.