Evidence map›Paper›PMID 37308998›Full record

ArticleCardiovascular diabetology2023

Duration-dependent impact of cardiometabolic diseases and multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants.

Yuting Han, Yizhen Hu, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Jingchao Liu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Yuting HanDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Yizhen HuDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Canqing YuDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Dianjianyi SunDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Yuanjie PangDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Pei PeiPeking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China.
Ling YangMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Yiping ChenMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Huaidong DuMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Jingchao LiuNCDs Prevention and Control Department, Wuzhong CDC, Suzhou, Jiangsu, China.
Dan SchmidtClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Daniel AveryClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Junshi ChenChina National Center for Food Safety Risk Assessment, Beijing, China.
Zhengming ChenClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Liming LiDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China. lmleeph@vip.163.com.
Jun LvDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China. lvjun@bjmu.edu.cn.
Peking University · CNUniversity of Oxford · GBMedical Research Council · GBChina National Center for Food Safety Risk Assessment · CN

Funding

Cancer Research UK 29186Medical Research Council MC_UU_00017/1
6 · The paper itself

Abstract

backgroundThe association of incident cardiometabolic multimorbidity (CMM) with mortality risk is rarely studied, and neither are the durations of cardiometabolic diseases (CMDs). Whether the association patterns of CMD durations with mortality change as individuals progress from one CMD to CMM is unclear.

methodsData from China Kadoorie Biobank of 512,720 participants aged 30-79 was used. CMM was defined as the simultaneous presence of two or more CMDs of interest, including diabetes, ischemic heart disease, and stroke. Cox regression was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the duration-dependent associations of CMDs and CMM with all-cause and cause-specific mortality. All information on exposures of interest was updated during follow-up.

resultsDuring a median follow-up of 12.1 years, 99,770 participants experienced at least one incident CMD, and 56,549 deaths were documented. Among 463,178 participants free of three CMDs at baseline, compared with no CMD during follow-up, the adjusted HRs (95% CIs) between CMM and all-cause mortality, mortality from circulatory system diseases, respiratory system diseases, cancer, and other causes were 2.93 (2.80-3.07), 5.05 (4.74-5.37), 2.72 (2.35-3.14), 1.30 (1.16-1.45), and 2.30 (2.02-2.61), respectively. All CMDs exhibited a high mortality risk in the first year of diagnosis. Subsequently, with prolonged disease duration, mortality risk increased for diabetes, decreased for IHD, and sustained at a high level for stroke. With the presence of CMM, the above association estimates inflated, but the pattern of which remained.

conclusionAmong Chinese adults, mortality risk increased with the number of the CMDs and changed with prolonged disease duration, the patterns of which varied among the three CMDs.

Indexed as

Cardiovascular DiseasesMyocardial IschemiaStrokeAdultCause of DeathHumansMultimorbidityProspective StudiesCardiometabolic diseaseMortalityMultimorbidityProspective cohort

Identifiers

PMID37308998
PMCPMC10262418
OpenAlexW4380369249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.