ArticleCardiovascular diabetology2023
Glycemic variability and in-hospital death of critically ill patients and the role of ventricular arrhythmias.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Predictive value of different glycemic variability indicators for prognosis in critically ill patients: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Glyceamic variability is a pridictor of in-hopital and long-term mortality of patients with dilated cardiomyopathy: a 5-year retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Association of mean blood glucose, glycemic variability, and their combined effect with 28-day mortality in critically ill ICU patients with acute myocardial infarction: a MIMIC-IV retrospective cohort study.Journal of thoracic disease · 2026Article
- An Inverted U-shaped Relationship between Glycemic Variability and Mortality in Patients with Severe Pulmonary Embolism: A Retrospective Study.Journal of atherosclerosis and thrombosis · 2026Article
- Association between glycemic variability and mortality after coronary stent implantation in critically ill patients: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Prognostic value of stress hyperglycemia ratio, hemoglobin glycation index, and glycemic variability for postoperative atrial fibrillation: a machine learning-based prediction model.BMC medical informatics and decision making · 2026Article
- Association between glycemic variability and all-cause mortality in patients with sepsis-associated acute respiratory distress syndrome: a retrospective study based on the MIMIC database.Journal of thoracic disease · 2026Article
- Association between stress hyperglycemia ratio and mortality of traumatic brain injury patients based on MIMIC-IV and eICU databases.BMC neurology · 2026Article
- Association of glycemic variability with the risk of new-onset atrial fibrillation and death in critically ill patients without diabetes: analysis of the MIMIC-IV database.Diabetology & metabolic syndrome · 2026Article
- Association of glycemic variability with short- and long-term mortality in critically ill patients with trauma.Scientific reports · 2025Article
- Independent and combined effects of mean blood glucose and glycemic variability on 28-day mortality in older acute myocardial infarction patients: a MIMIC-IV cohort study.BMC geriatrics · 2025Article
- Association of Average Glucose and Glycemic Variability With 28-Day Mortality in Patients With Cardiac Arrest: A Retrospective Study.Journal of diabetes · 2025Article
- Prognostic significance of postoperative glycemic variability after gastric surgery: a retrospective cohort study and development of a mortality prediction model.European journal of medical research · 2025Article
- Postoperative glycemic variability as a predictor for one-year mortality following coronary artery bypass grafting: a retrospective cohort study.BMC cardiovascular disorders · 2025Article
- Relationship between hemoglobin glycation index and all-cause mortality in patients with acute myocardial infarction: based on MIMIC-IV database.Diabetology & metabolic syndrome · 2025Article
- Association between hemoglobin glycation index and mortality in surgical ICU patients.Scientific reports · 2025Article
- Prognostic value of glycaemic variability for mortality in cardiogenic shock patients: a retrospective cohort study.Cardiovascular diabetology · 2025Article
- Current status and mechanistic insights into nontarget coronary lesions in patients with diabetes and early abnormal glucose metabolism.World journal of diabetes · 2025Review
- Stress Hyperglycemia Ratio Outperforms Glycemic Variability in Predicting Mortality Among Acute Myocardial Infarction Patients With Reduced Ejection Fraction: A Retrospective Cohort Study.Journal of diabetes · 2025Article
- Association Between Glycemic Variability and All-Cause Mortality in Patients with Acute Pancreatitis in the Intensive Care Unit: A Retrospective Analysis.Digestive diseases and sciences · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormal glycemic variability is common in the intensive care unit (ICU) and is associated with increased in-hospital mortality and major adverse cardiovascular events, but little is known about whether adverse outcomes are partly mediated by ventricular arrhythmias (VA). We aimed to explore the association between glycemic variability and VA in the ICU and whether VA related to glycemic variability mediate the increased risk of in-hospital death.
methodsWe extracted all measurements of blood glucose during the ICU stay from The Medical Information Mart for Intensive Care IV (MIMIC-IV) database version 2.0. Glycemic variability was expressed by the coefficient of variation (CV), which was calculated by the ratio of standard deviation (SD) and average blood glucose values. The outcomes included the incidence of VA and in-hospital death. The KHB (Karlson, KB & Holm, A) is a method to analyze the mediation effect for nonlinear models, which was used to decompose the total effect of glycemic variability on in-hospital death into a direct and VA-mediated indirect effect.
resultsFinally, 17,756 ICU patients with a median age of 64 years were enrolled; 47.2% of them were male, 64.0% were white, and 17.8% were admitted to the cardiac ICU. The total incidence of VA and in-hospital death were 10.6% and 12.8%, respectively. In the adjusted logistic model, each unit increase in log-transformed CV was associated with a 21% increased risk of VA (OR 1.21, 95% CI: 1.11-1.31) and a 30% increased risk (OR 1.30, 95% CI: 1.20-1.41) of in-hospital death. A total of 3.85% of the effect of glycemic variability on in-hospital death was related to the increased risk of VA.
conclusionHigh glycemic variability was an independent risk factor for in-hospital death in ICU patients, and the effect was caused in part by an increased risk of VA.
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