Evidence map›Paper›PMID 37308884›Full record

Observational studyBMC infectious diseases2023

Memory B-cells are enriched in the blood of patients with acute Buruli ulcer disease: a prospective observational study.

Jonathan Kofi Adjei, Wilfred Aniagyei, Ernest Adankwah, Julia Seyfarth, Ertan Mayatepek, Daniel Antwi Berko, Nancy Ackam, Max Efui Annani-Akollor, Samuel Asamoah Sakyi, Yaw Ampem Amoako and 3 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jonathan Kofi AdjeiKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Wilfred AniagyeiKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Ernest AdankwahKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Julia SeyfarthDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Ertan MayatepekDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Daniel Antwi BerkoKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Nancy AckamKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Max Efui Annani-AkollorDepartment of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Samuel Asamoah SakyiDepartment of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Yaw Ampem AmoakoKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Dorcas OwusuKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Marc JacobsenDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Richard Odame PhillipsKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana. rodamephillips@gmail.com.
Kumasi Centre for Collaborative Research in Tropical Medicine · GHKwame Nkrumah University of Science and Technology · GHDüsseldorf University Hospital · DE

Funding

Deutsche Forschungsgemeinschaft JA 1479/5-1European and Developing Countries Clinical Trials Partnership 101897 BuruliNox 7
6 · The paper itself

Abstract

backgroundBuruli ulcer disease (BUD) caused by Mycobacterium (M.) ulcerans is characterized by necrotic skin lesions. As for other mycobacterial infections, e.g., tuberculosis, the immune response is important for host protection. B-cells may play a role in antimycobacterial immunity but studies characterizing the B-cell repertoire and memory generation in BUD and during the course of treatment are scarce.

methodsWe investigated the adaptive immune cell repertoire in children with BUD and healthy matched controls by flow cytometry. Analyses prior to treatment, also in a study group of patients with tuberculosis, as well as three time points during BUD treatment (i.e., week 8, 16, and 32) were performed. In addition, BUD disease severity as well as treatment response were analysed for association with B-cell repertoire differences.

resultsChildren with BUD had comparable total B- and T-cell proportions but differed largely in B-cell subsets. Memory B-cell (B

conclusionsThese results suggest a role of B-cell subsets in the immune response against M. ulcerans. Furthermore, changes in B-cell subset proportions may be used as markers for treatment monitoring in BUD.

Indexed as

Buruli UlcerMycobacterium InfectionsB-LymphocytesChildFlow CytometryHumansMemory B CellsB-cell subsetsBiomarkerBuruli ulcerMycobacterium ulcerans

Identifiers

PMID37308884
PMCPMC10259001
OpenAlexW4380323981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.