Evidence map›Paper›PMID 37308869›Full record

ArticleBMC cancer2023

An integrated model for prognosis in vulvar squamous cell carcinoma.

Tao Zhang, Yingfan Zhu, Jie Luo, Juanqing Li, Shuang Niu, Hao Chen, Feng Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tao ZhangDepartment of Gynecology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, 310006, China.
Yingfan ZhuDepartment of Gynecology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, 310006, China.
Jie LuoDepartment of Gynecology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, 310006, China.
Juanqing LiDepartment of Gynecology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, 310006, China.
Shuang NiuDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Hao ChenDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Hao.Chen@UTSouthwestern.edu.
Feng ZhouDepartment of Pathology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, 310006, China. fungchew@zju.edu.cn.
Women's Hospital, School of Medicine, Zhejiang University · CNSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVulvar squamous cell carcinoma (VSCC) is a relatively rare gynecologic cancer. Unlike cervical squamous cell carcinoma (CSCC), in which nearly all cases are caused by HPV infection, most VSCCs are HPV-independent. Patients with VSCC also have worse overall survival (OS) than those with CSCC. Unlike CSCC, the risk factors of VSCC have not been extensively studied. Here, we investigated the prognostic values of clinicopathological parameters as well as biomarkers in patients with VSCC.

methodsIn total, 69 cases of VSCC accessions were selected for analysis between April 2010 and October 2020. The risk factors of VSCC were screened using Cox models to establish nomograms for predicting survival outcomes.

resultsFollowing the multivariate COX model for OS, independent predictors including advanced age (hazard ratio [HR] 5.899, p = 0.009), HPV positivity (HR 0.092, p = 0.016), high Ki-67 index (HR 7.899, p = 0.006), PD-L1-positivity (HR 4.736, p = 0.077), and CD8 + tumor-infiltrating lymphocytes (TILs) (HR 0.214, p = 0.024) were included in the nomogram for OS; multivariate COX model for progression-free survival (PFS) was used to screen prognostic factors including advanced age (HR 2.902, p = 0.058), lymph node metastasis (HR 5.038, p = 0.056), HPV positivity (HR 0.116, p = 0.011), high Ki-67 index (HR 3.680, p = 0.042), PD-L1-positivity (HR 5.311, p = 0.045), and CD8 + TILs (HR 0.236, p = 0.014) to establish the PFS nomogram model. Based on the C-index (0.754 for OS and 0.754 for PFS) from our VSCC cohort and the corrected C-index (0.699 for OS and 0.683 for PFS) from an internal validation cohort, the nomograms demonstrated good predictive and discriminative ability. Kaplan-Meier curves also supported the excellent performance of the nomograms.

conclusionOur prognostic nomograms suggested that (1) shorter OS and PFS were associated with PD-L1-positivity, high Ki-67 index, and low CD8 + TILs; (2) HPV-independent tumors were associated with poorer survival outcome, and mutant p53 status showed no prognostic significance.

Indexed as

Carcinoma, Squamous CellPapillomavirus InfectionsVulvar NeoplasmsB7-H1 AntigenFemaleHumansKi-67 AntigenPrognosisB7-H1 AntigenKi-67 AntigenCD8HPVKi-67Nomogramp53PD-L1PrognosisVulvar squamous cell carcinoma

Identifiers

PMID37308869
PMCPMC10259032
OpenAlexW4380364315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.