Evidence map›Paper›PMID 37308684›Full record

ArticlePediatric research2023

Early assessment of injury with optical markers in a piglet model of neonatal encephalopathy.

Kelly Harvey-Jones, Frederic Lange, Vinita Verma, Gemma Bale, Christopher Meehan, Adnan Avdic-Belltheus, Mariya Hristova, Magdalena Sokolska, Francisco Torrealdea, Xavier Golay and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Kelly Harvey-JonesInstitute for Women's Health, University College London, London, UK.
Frederic LangeDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Vinita VermaInstitute for Women's Health, University College London, London, UK.
Gemma BaleDepartment of Engineering and Department of Physics, University of Cambridge, Cambridge, UK.
Christopher MeehanInstitute for Women's Health, University College London, London, UK.
Adnan Avdic-BelltheusInstitute for Women's Health, University College London, London, UK.
Mariya HristovaInstitute for Women's Health, University College London, London, UK.
Magdalena SokolskaMedical Physics and Biomedical Engineering, University College London Hospital, London, UK.
Francisco TorrealdeaMedical Physics and Biomedical Engineering, University College London Hospital, London, UK.
Xavier GolayInstitute of Neurology, University College London, London, UK.
Veronika ParfentyevaICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain.
Turgut DurduranICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain.
Alan BainbridgeMedical Physics and Biomedical Engineering, University College London Hospital, London, UK.
Ilias TachtsidisDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Nicola J RobertsonInstitute for Women's Health, University College London, London, UK.
Subhabrata MitraInstitute for Women's Health, University College London, London, UK. subhabrata.mitra.13@ucl.ac.uk.
University College London · GBUniversity College Hospital · GBInstitució Catalana de Recerca i Estudis Avançats · ESInstitute for Reproductive Health · USInstitute of Photonic Sciences · ESLondon Women's Clinic · GBUniversity of Cambridge · GB

Funding

Department of HealthMedical Research Council MR/S003134/1Wellcome Trust 219610/Z/19/Z
6 · The paper itself

Abstract

backgroundOpportunities for adjunct therapies with cooling in neonatal encephalopathy are imminent; however, robust biomarkers of early assessment are lacking. Using an optical platform of broadband near-infrared spectroscopy and diffuse correlation spectroscopy to directly measure mitochondrial metabolism (oxCCO), oxygenation (HbD), cerebral blood flow (CBF), we hypothesised optical indices early (1-h post insult) after hypoxia-ischaemia (HI) predicts insult severity and outcome.

methodsNineteen newborn large white piglets underwent continuous neuromonitoring as controls or following moderate or severe HI. Optical indices were expressed as mean semblance (phase difference) and coherence (spectral similarity) between signals using wavelet analysis. Outcome markers included the lactate/N-acetyl aspartate (Lac/NAA) ratio at 6 h on proton MRS and TUNEL cell count.

resultsCBF-HbD semblance (cerebrovascular dysfunction) correlated with BGT and white matter (WM) Lac/NAA (r

conclusionOptical markers of both cerebral metabolic and vascular dysfunction 1 h after HI predicted injury severity and subsequent outcome in a pre-clinical model. IMPACT: This study highlights the possibility of using non-invasive optical biomarkers for early assessment of injury severity following neonatal encephalopathy, relating to the outcome. Continuous cot-side monitoring of these optical markers can be useful for disease stratification in the clinical population and for identifying infants who might benefit from future adjunct neuroprotective therapies beyond cooling.

Indexed as

Hypoxia-Ischemia, BrainAnimalsAnimals, NewbornBiomarkersBrainHumansInfantNeuroprotectionSwineBiomarkers

Identifiers

PMID37308684
PMCPMC10624614
OpenAlexW4380423022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.