ArticleScientific reports2023
Transcriptome and metabonomics combined analysis revealed the energy supply mechanism involved in fruiting body initiation in Chinese cordyceps.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 15 citations in OpenAlex.
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- Transcriptomic Profiling of Developmental Stages and Screening of Candidate Genes inJournal of fungi (Basel, Switzerland) · 2026Article
- NADPH Dehydrogenase Gene Regulates Energy Distribution and Fatty Acid Metabolism During Fruiting Body Formation in the Filamentous Fungus Podospora anserina.Microbial biotechnology · 2026Article
- Research advances on Cordyceps sinensis and its components in relation to omics biomarkers for the neurological disorders.Die Naturwissenschaften · 2026Review
- Identification of regulatory candidate genes for Lentinula edodes pileus development based on transcriptome analysis.G3 (Bethesda, Md.) · 2026Article
- Integrated Transcriptomic and Metabolomic Profiling Reveals Monotonic Molecular Signatures During Fruiting Body Development ofJournal of fungi (Basel, Switzerland) · 2025Article
- Untargeted Metabolomics-Based Characterization of the Metabolic Profile and Antioxidant Activity ofJournal of fungi (Basel, Switzerland) · 2025Article
- Multi-omics insights into growth and fruiting body development in the entomopathogenic fungusIMA fungus · 2025Article
- Combined metabolome and transcriptome analysis reveal the mechanism of water stress in Ophiocordyceps sinensis.BMC genomics · 2024Article
- Genome Analysis ofInternational journal of molecular sciences · 2024Article
- Combined transcriptome and metabolome analysis of sugar and fatty acid of aromatic coconut and non-aromatic coconut in China.Food chemistry. Molecular sciences · 2024Article
- Rapid discrimination between wild and cultivatedCurrent research in food science · 2024Article
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6 authors at 1 institution in 1 country.
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Abstract
Chinese cordyceps was one of most valuable traditional Chinese medicine fungi. To elucidate the molecular mechanisms related to energy supply mechanism involved in the initiation and formation of primordium in Chinese cordyceps, we performed the integrated metabolomic and transcriptomic analyses of it at pre-primordium period, primordium germination period and after-primordium period, respectively. Transcriptome analysis showed that many genes related to 'starch and sucrose metabolism', 'fructose and mannose metabolism', 'linoleic acid metabolism', 'fatty acids degradation' and 'glycerophospholipid metabolism' were highly up-regulated at primordium germination period. Metabolomic analysis showed many metabolites regulated by these genes in these metabolism pathways were also markedly accumulated at this period. Consequently, we inferred that carbohydrate metabolism and β-oxidation pathway of palmitic acid and linoleic acid worked cooperatively to generate enough acyl-CoA, and then entered TCA cycle to provide energy for fruiting body initiation. Overall, our finding provided important information for further exploring the energy metabolic mechanisms of realizing the industrialization of Chinese cordyceps artificial cultivation.
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