Evidence map›Paper›PMID 37308620›Full record

ArticleTranslational stroke research2024

Longitudinal Morphometric Changes in the Corticospinal Tract Shape After Hemorrhagic Stroke.

Seth B Boren, Sean I Savitz, Nicole Gonzales, Khader Hasan, Andrea Becerril-Gaitan, Vahed Maroufy, Yuan Li, James Grotta, Emily A Steven, Ching-Jen Chen and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Seth B BorenInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77030, USA.
Sean I SavitzInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77030, USA.
Nicole GonzalesInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77030, USA.
Khader HasanDepartment of Interventional Diagnostic Radiology, McGovern Medical School, The University of Texas Health Science Center, Houston, USA.
Andrea Becerril-GaitanDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center, Houston, USA.
Vahed MaroufyDepartment of Biostatistics and Data Science, School of Public Health, McGovern Medical School, The University of Texas Health Science Center, Houston, USA.
Yuan LiDepartment of Biostatistics and Data Science, School of Public Health, McGovern Medical School, The University of Texas Health Science Center, Houston, USA.
James GrottaStroke Research and Mobile Stroke Unit, Department of Neurology, Memorial Hermann Hospital, Houston, USA.
Emily A StevenInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77030, USA.
Ching-Jen ChenDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center, Houston, USA.
Clark W SittonDepartment of Interventional Diagnostic Radiology, McGovern Medical School, The University of Texas Health Science Center, Houston, USA.
Jaroslaw AronowskiInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77030, USA.
Muhammad E HaqueInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77030, USA. Muhammad.E.Haque@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USMemorial Hermann · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep intracerebral hemorrhage (ICH) exerts a direct force on corticospinal tracts (CST) causing shape deformation. Using serial MRI, Generalized Procrustes Analysis (GPA), and Principal Components Analysis (PCA), we temporally evaluated the change in CST shape. Thirty-five deep ICH patients with ipsilesional-CST deformation were serially imaged on a 3T-MRI with a median imaging time of day-2 and 84 of onset. Anatomical and diffusion tensor images (DTI) were acquired. Using DTI color-coded maps, 15 landmarks were drawn on each CST and the centroids were computed in 3 dimensions. The contralesional-CST landmarks were used as a reference. The GPA outlined the shape coordinates and we superimposed the ipsilesional-CST shape at the two-time points. A multivariate PCA was applied to identify eigenvectors associated with the highest percentile of change. The first three principal components representing CST deformation along the left-right (PC1), anterior-posterior (PC2), and superior-inferior (PC3) respectively were responsible for 57.9% of shape variance. The PC1 (36.1%, p < 0.0001) and PC3 (9.58%, p < 0.01) showed a significant deformation between the two-time points. Compared to the contralesional-CST, the ipsilesional PC scores were significantly (p < 0.0001) different only at the first-timepoint. A significant positive association between the ipsilesional-CST deformation and hematoma volume was observed. We present a novel method to quantify CST deformation caused by ICH. Deformation most often occurs in left-right axis (PC1) and superior-inferior (PC3) directions. As compared to the reference, the significant temporal difference at the first time point suggests CST restoration over time.

Indexed as

Diffusion Tensor ImagingPyramidal TractsAdultAgedAged, 80 and overCerebral HemorrhageFemaleHemorrhagic StrokeHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedPrincipal Component AnalysisCorticospinal tractsDiffusion tensor imagingGeneralized procrustes analysisIntracerebral hemorrhageMorphometricsPrincipal component analysisSerial magnetic resonance imagingStroke

Identifiers

PMID37308620
OpenAlexW4380423069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.