ArticleScientific reports2023
Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children's Study.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.Frontiers in neuroscience · 2026Pooled it
- The equity and effectiveness of China's 2009 folic acid supplementation programme for long-term child development.Global health action · 2026Article
- Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity.Nutrients · 2026Review
- A new perspective on the association between maternal folic acid supplementation across the perinatal period and cognitive and behavioral outcomes in children at age 4: findings from the MABC birth cohort study.European journal of nutrition · 2025Article
- Neurobehavioral Outcomes of Children with Antenatal Exposure to Antiseizure Medications: Correspondence.Indian journal of pediatrics · 2025Article
- Association of air purifier usage during pregnancy with adverse birth outcomes: the Japan Environment and Children's Study.BMC public health · 2024Article
- Breastfeeding and Children's Cognitive Development up to the Age of 4 Years: The Japan Environment and Children's Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024Article
- Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life.Frontiers in nutrition · 2024Article
- Advances in Folic Acid Biosensors and Their Significance in Maternal, Perinatal, and Paediatric Preventive Medicine.Biosensors · 2023Review
Corrections and comments
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Authors and funding
16 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the association between maternal prenatal folic acid supplement use/dietary folate intake and cognitive development in 4-year-old offspring (N = 3445) using data from the Japan Environment and Children's Study. Cognitive development was evaluated using the Kyoto Scale of Psychological Development 2001. Multiple regression analysis revealed that offspring of mothers who started using folic acid supplements pre-conception had a significantly higher language-social developmental quotient (DQ) (partial regression coefficient 1.981, 95% confidence interval 0.091 to 3.872) than offspring of mothers who did not use such supplements at any time throughout their pregnancy (non-users). Offspring of mothers who started using folic acid supplements within 12 weeks of gestation had a significantly higher cognitive-adaptive (1.489, 0.312 to 2.667) and language-social (1.873, 0.586 to 3.159) DQ than offspring of non-users. Regarding daily dietary folate intake from preconception to early pregnancy, multiple regression analysis revealed that there was no significant association with any DQ area in the 200 to < 400 µg and the ≥ 400 µg groups compared with the < 200 µg group. Maternal prenatal folic acid supplementation starting within 12 weeks of gestation (but not adequate dietary folate intake from preconception to early pregnancy) is positively associated with cognitive development in 4-year-old offspring.
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