ArticleNature communications2023
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 3 pooled it
39.6field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
181 citing papers in PubMed, 3 syntheses or guidelines pooled it, 241 citations in OpenAlex.
- Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nature communications · 2026Pooled it
- GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.Nature communications · 2025Pooled it
- Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders.Frontiers in immunology · 2025Pooled it
- Rapid response of lichen planus to baricitinib associated with suppression of cytotoxic CXCL13+CD8+ T cells.The Journal of clinical investigation · 2024Trial
- The regnase family in autoimmune diseases: a regnase-1-centered perspective on cellular heterogeneity.Molecular biology reports · 2026Review
- Exploring the role of neuro-immune modulation for psoriasis management: a narrative review of existing evidence and future therapies.Brain, behavior, & immunity - health · 2026Review
- Single-cell RNA sequencing reveals the interaction of TREM2Immunologic research · 2026Article
- Myeloid infiltration and epidermal dysregulation characterize cutaneous photosensitivity in systemic lupus erythematosus.Science translational medicine · 2026Article
- Layer-Specific Dermal and Subcutaneous Delivery via Modular LNP-Hydrogel-Integrated Threaded Microneedles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multi-Omics Analysis Identifies Fibroblast-Associated Stromal-Immune Networks Linked to Pregnancy-Associated Attenuation of Imiquimod-Induced Psoriatic Dermatitis.Biomedicines · 2026Article
- NAT10 aggravates psoriasis by promoting keratinocytes fatty acid synthesis via stable FASN transcription.Journal of pharmaceutical analysis · 2026Article
- LCN2-Driven Fibroblast Ferroptosis-Associated Injury Promotes Keratinocyte Proliferation via Lipid Peroxidation Signaling in Psoriasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Periostin drives psoriasis progression through the stimulation of cutaneous nerve fibers.iScience · 2026Article
- Fibroblasts resistScience advances · 2026Article
- Tumor-Infiltrating mregDCs Restrain Anti-Tumor Immunity in Early Relapse HCC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.Nature communications · 2026Article
- Sensory neurons shape γδ T cell effector programs to control Psoriasiform Inflammation.bioRxiv : the preprint server for biology · 2026Article
- BLASE: bulk linkage analysis for single cell experiments - teasing out the secrets of bulk transcriptomics with trajectory analysis.BMC methods · 2026Article
- Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis.EMBO molecular medicine · 2026Article
- GPR107 promotes autophagy secretion in psoriatic keratinocytes by inhibiting BECN1 K48-linked ubiquitination.Cell death & disease · 2026Article
121 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 6 institutions in 2 countries.
Feiyang MaDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-6260-0787
Olesya PlazyoDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Allison C BilliDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Xianying XingDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Rachael WasikowskiDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-3544-3023
Mehrnaz Gharaee-KermaniDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Grace HileDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Yanyun JiangDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Paul W HarmsDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-0802-2883
Enze XingDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-9358-9368
Joseph KirmaDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Jingyue XiDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Jer-En HsuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Mrinal K SarkarDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-8505-4259
Yutein ChungDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.
Jeremy Di DomizioDepartment of Dermatology, University Hospital of Lausanne, 1011, Lausanne, Switzerland.ORCID 0000-0002-6281-3918
Michel GillietDepartment of Dermatology, University Hospital of Lausanne, 1011, Lausanne, Switzerland.ORCID 0000-0002-4609-3762
Nicole L WardDepartment of Dermatology, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID 0000-0003-1907-2621
Emanual MaverakisDepartment of Dermatology, University of California Davis, Sacramento, CA, USA.ORCID 0000-0002-6294-6294
Eynav KlechevskyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0001-6121-1571
John J VoorheesDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-1856-785X
James T ElderDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-4215-3294
Jun Hee LeeDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2200-6011
J Michelle KahlenbergDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-4006-8945
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Robert L ModlinDivision of Dermatology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0003-4720-031X
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA. johanng@med.umich.edu.ORCID 0000-0002-0080-0812
University of Michigan · USUniversity Hospital of Lausanne · CHUniversity of California, Los Angeles · USCase Western Reserve University · USUniversity of California, Davis · USWashington University in St. Louis · US
Funding
Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7MTCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4MLinkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1MELLIPSS: ELucidating the Landscape of Immunoendotypes in Psoriatic Skin and SynoviumUC2AR081029 · NIAMS · UNIVERSITY OF ROCHESTER · PI Johann Eli Gudjonsson, Wilson Liao · 2022 to 2026
$7.9MUniversity of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDRZEJ A. DLUGOSZ · 2019 to 2026
$6.6MPsoriasis Center of Research TranslationP50AR070590 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI CAMERON, MARK JAMES · 2017 to 2021
$6.5MUniversity of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1MKallikrein-PAR interactions in skin inflammationR01AR073196 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARD, NICOLE LEANNE · 2018 to 2023
$3.3MCombined Analysis of Gene Expression and DNA Variation in PsoriasisR01AR054966 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2007 to 2011
$3.2MThe skin microbiome in acneR01AR074302 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GALLO, RICHARD L, MODLIN, ROBERT L · 2018 to 2022
$2.6MRole of IL-13 and the IL-13 Associated rs20541 Risk Variant in the Pathogenesis of PsoriasisR01AR069071 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2015 to 2019
$2.1MHarnessing Human Dendritic Cell Subsets in Skin for the Design of Novel ImmunotherapiesR01AR075959 · NIAMS · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2019 to 2023
$1.7MNCI NIH HHS UG3 CA268091NIAID NIH HHS R01 AI022553NIAMS NIH HHS K01 AR072129NIAMS NIH HHS K08 AR078251NIAMS NIH HHS P30 AR075043NIAMS NIH HHS P50 AR070590NIAMS NIH HHS R01 AR040312NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01 AR054966NIAMS NIH HHS R01 AR069071NIAMS NIH HHS R01 AR073196NIAMS NIH HHS R01 AR074302NIAMS NIH HHS R01 AR075959NIAMS NIH HHS UC2 AR081029NIGMS NIH HHS R25 GM086262
Abstract
The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil proteases, which primarily occur within the supraspinous layer of the psoriatic epidermis. We further show that a subset of SFRP2
Indexed as
KeratinocytesPsoriasisEpidermal CellsFibroblastsHumansSkin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.