ArticleClinica chimica acta; international journal of clinical chemistry2023
Ethical issues in the use of leftover samples and associated personal data obtained from diagnostic laboratories.
Article in Clinica chimica acta; international journal of clinical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
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- Validation of on-slide immunocytochemistry controls prepared from long-term preserved prefixed cell suspensions.Cancer cytopathology · 2026Article
- Fluoride-Oxalate and Lithium Heparin Anticoagulant Tubes Are Reliable Alternatives to EDTA for HbA1c Measurement.BioMed research international · 2026Article
- Development and validation of a method for quantitation of CTx-1 for the assessment of biosimilarity of FKS518, a denosumab biosimilar.Bioanalysis · 2025Article
- Immune Cell Dynamics in Cardiac Diseases: Insights From Single-Cell Sequencing.Journal of cellular and molecular medicine · 2025Review
- European Preparedness for Japanese Encephalitis Virus Through Alignment of Animal Health Laboratory Diagnosis.Transboundary and emerging diseases · 2025Article
- Substantial loss of T cells upon lymphocyte isolation from heparin-anticoagulated peripheral blood.Frontiers in immunology · 2025Article
- Article
- Storage, Retention, and Use of Leftover Pathology Specimens: The Underestimated Treasures.Cureus · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnostic laboratories are an integral part of the research ecosystem in biomedical sciences. Among other roles, laboratories are a source of clinically-characterized samples for research or diagnostic validation studies. Particularly during the COVID-19 pandemic, this process was entered by laboratories with different experience in the ethical management of human samples. The objective of this document is to present the current ethical framework regarding the use of leftover samples in clinical laboratories. Leftover samples are defined as the residue of a sample that has been obtained and used for clinical purposes, and would otherwise be discarded. Secondary use of samples typically demands institutional ethical oversight and informed consent by the participants, although the latter requirement could be exempted when the harm risks are sufficiently small. However, ongoing discussions have proposed that minimal risk is an insufficient argument to allow the use of samples without consent. In this article, we discuss both positions, to finally suggest that laboratories anticipating the secondary use of samples should consider the adoption of broad informed consent, or even the implementation of organized biobanking, in order to achieve higher standards of ethical compliance which would enhance their capacity to fulfill their role in the production of knowledge.
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