Evidence map›Paper›PMID 37307962›Full record

ArticleInternational journal of pharmaceutics2023

Effects of different mesh nebulizer sources on the dispersion of powder formulations produced with a new small-particle spray dryer.

Ghali Aladwani, Mohammad A M Momin, Benjamin Spence, Dale R Farkas, Serena Bonasera, Amr Hassan, Michael Hindle, Worth Longest

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ghali AladwaniDepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Mohammad A M MominDepartment of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, United States.
Benjamin SpenceDepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Dale R FarkasDepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Serena BonaseraDepartment of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, United States.
Amr HassanDepartment of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, United States.
Michael HindleDepartment of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, United States.
Worth LongestDepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, United States. Electronic address: pwlongest@vcu.edu.

Funding

High Efficiency Aerosol Delivery using the Excipient Enhanced Growth Concept: A Human Proof of Concept StudyR01HL107333 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HINDLE, MICHAEL, LONGEST, P. WORTH · 2011 to 2020
$4.2M
High Efficiency Delivery of Surfactant Aerosols to Infants without IntubationR01HL139673 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HINDLE, MICHAEL, LONGEST, P. WORTH · 2018 to 2021
$2.8M
Preclinical development of a synthetic lung surfactant dry powder aerosol for acute respiratory distress syndrome patients receiving different modes of ventilation supportR56HL164508 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LONGEST, P. WORTH · 2022 to 2022
$719k
NHLBI NIH HHS R01 HL107333NHLBI NIH HHS R01 HL139673NHLBI NIH HHS R56 HL164508
6 · The paper itself

Abstract

The objective of this study was to explore the aerosolization performance of powders produced with different mesh nebulizer sources in the initial design of a new small-particle spray dryer system. An aqueous excipient enhanced growth (EEG) model formulation was spray dried using different mesh sources and the resulting powders were characterized based on (i) laser diffraction, (ii) aerosolization with a new infant air-jet dry powder inhaler, and (iii) aerosol transport through an infant nose-throat (NT) model ending with a tracheal filter. While few differences were observed among the powders, the medical-grade Aerogen Solo (with custom holder) and Aerogen Pro mesh sources were selected as lead candidates that produced mean fine particle fractions <5 µm and <1 µm in ranges of 80.6-77.4% and 13.1-16.0%, respectively. Improved aerosolization performance was achieved at a lower spray drying temperature. Lung delivery efficiencies through the NT model were in the range of 42.5-45.8% for powders from the Aerogen mesh sources, which were very similar to previous results with a commercial spray dryer. Ultimately, a custom spray dryer that can accept meshes with different characteristics (e.g., pore sizes and liquid flow rates) will provide particle engineers greater flexibility in producing highly dispersible powders with unique characteristics.

Indexed as

Chemistry, PharmaceuticalSurgical MeshAdministration, InhalationAerosolsDry Powder InhalersHumansParticle SizePowdersAerosolsPowdersAir-jet dry powder inhalerDry powder aerosolInfant aerosol deliveryParticle dispersionParticle engineeringSpray dryer design

Identifiers

PMID37307962
PMCPMC10527815

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.