ArticleAging and disease2024
Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function.
Abstract readValidation Study
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Article in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 1 of them a synthesis that pooled it.
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123citing papers in PubMed, 1 pooled it
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Who cites it
123 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glymphatic dysfunction in Alzheimer's disease: a systematic review and meta-analysis of the DTI-ALPS index as an imaging biomarker.Frontiers in aging neuroscience · 2026Pooled it
- Age, Multidomain Lifestyle Intervention, and White Matter Integrity: Secondary Analysis of the POINTER Randomized Clinical Trial.JAMA network open · 2026Trial
- Dissociable associations of free-water fraction and DTI-ALPS index with disease manifestation and mutation carrier status in Parkinson's disease.Japanese journal of radiology · 2026Article
- Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Glymphatic System Dysfunction and its Associated Factors in Wilson's Disease: A DTI-ALPS Study.Brain and behavior · 2026Article
- The impaired hemodynamics of choroid plexus and its interactions within the glymphatic system in Parkinson's disease.GeroScience · 2026Article
- Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community-Dwelling Older Adults.CNS neuroscience & therapeutics · 2026Article
- DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging: A 3-Year Longitudinal Study.Human brain mapping · 2026Article
- Altered Neurofluid Dynamics Markers in Middle-Aged and Older Women With Insomnia: A Multiparametric MR Neuroimaging Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Diffusion tensor image analysis along the perivascular space (DTI-ALPS): redefining its interpretation and role.Japanese journal of radiology · 2026Review
- DTI-ALPS as a marker of glymphatic function: Review of the literature findings, methodology, and interpretation.Neuroimage. Reports · 2026Article
- Choroid Plexus Microstructural Alterations Link Glymphatic Dysfunction and White Matter Degeneration in Parkinson's Disease.CNS neuroscience & therapeutics · 2026Article
- Retinal microvascular changes are related to indicators of glymphatic dysfunction and small vessel disease in frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn's disease.Journal of gastroenterology · 2026Article
- Are perivascular spaces truly incidental? Evidence of structural-diffusion coupling in healthy young adults.Acta neurologica Belgica · 2026Article
- Multimodal Neuroimaging-Based Machine Learning Models Leveraging Cerebral Morphometry and Glymphatic Parameters Predict Short-Term Post-Programming STN-DBS Motor Response in Parkinson's Disease.CNS neuroscience & therapeutics · 2026Article
- Reduced glymphatic function in autism revealed by the diffusion tensor analysis along the perivascular space index.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease.iScience · 2026Article
- Anatomical determinants of DTI-ALPS: effects of ROI definition, ventricular morphology, and periventricular deformation.bioRxiv : the preprint server for biology · 2026Article
- White matter microstructural and network abnormalities in periventricular leukomalacia and their association with motor severity.Neuroradiology · 2026Article
63 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors.
Xiaodan LiuLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Giuseppe BarisanoDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Xingfeng ShaoLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Kay JannLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
John M RingmanDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Konstantinos ArfanakisDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Arvind CaprihanThe Mind Research Network, Albuquerque, NM, USA.
Charles DeCarliDepartment of Neurology, University of California, Davis, Davis, CA, USA.
Brian T GoldDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Pauline MaillardDepartment of Neurology, University of California, Davis, Davis, CA, USA.
Claudia L SatizabalPopulation Health Sciences and Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Elyas FadaeeNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Mohamad HabesNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Lara StablesDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Herpreet SinghDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Bruce FischlDepartment of Radiology, Harvard Medical School, Boston, MA, USA.
Andre van der KouweDepartment of Radiology, Harvard Medical School, Boston, MA, USA.
Kristin SchwabDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Karl G HelmerDepartment of Radiology, Harvard Medical School, Boston, MA, USA.
Steven M GreenbergDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Danny J J WangLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
MarkVCID Consortium
Funding
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI OLICHNEY, JOHN M · 1991 to 2020
$28.3MUSCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8MUC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEE-WAY JIN · 2021 to 2026
$25.2MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MUniversity of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5MVCID Biomarkers Coordinating CenterU24NS100591 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg · 2016 to 2026
$19.8MValidation of Biomarkers of Small Vessel Injury in VCIDUF1NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2021 to 2023
$6.3MValidation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationU01NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2023 to 2025
$3.9MNovel imaging and endothelial biomarkers of small vessel cerebrovascular diseaseUH3NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DECARLI, CHARLES, KRAMER, JOEL H · 2018 to 2020
$3.5MLongitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaU01NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2023 to 2025
$3.5MSmall vessel disease biomarkers in a longitudinally-followed "stroke-belt" cohortUH3NS100606 · NINDS · UNIVERSITY OF KENTUCKY · PI JICHA, GREGORY A, WILCOCK, DONNA M · 2018 to 2020
$3.4MMultiethnic Validation of VCID Biomarkers in South TexasU01NS125513 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SATIZABAL, CLAUDIA L · 2023 to 2025
$3.3MNIA NIH HHS P20 AG068077NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072972NINDS NIH HHS U01 NS100599NINDS NIH HHS U01 NS100608NINDS NIH HHS U01 NS100614NINDS NIH HHS U01 NS125513NINDS NIH HHS U24 NS100591NINDS NIH HHS UF1 NS100588NINDS NIH HHS UF1 NS100598NINDS NIH HHS UF1 NS100599NINDS NIH HHS UF1 NS100608NINDS NIH HHS UF1 NS100614NINDS NIH HHS UF1 NS125513NINDS NIH HHS UH2 NS100588NINDS NIH HHS UH2 NS100598NINDS NIH HHS UH2 NS100599NINDS NIH HHS UH2 NS100605NINDS NIH HHS UH2 NS100606NINDS NIH HHS UH2 NS100608NINDS NIH HHS UH2 NS100614NINDS NIH HHS UH3 NS100605NINDS NIH HHS UH3 NS100606NINDS NIH HHS UH3 NS100608
Abstract
The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.
Indexed as
Diffusion Tensor ImagingGlymphatic SystemAdultFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedReproducibility of ResultsSoftware
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