Evidence map›Paper›PMID 37307566›Full record

ArticleMolecular biology and evolution2023

A Quantitative Theory for Genomic Offset Statistics.

Clément Gain, Bénédicte Rhoné, Philippe Cubry, Israfel Salazar, Florence Forbes, Yves Vigouroux, Flora Jay, Olivier François

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Population structure limits the use of genomic data for predicting phenotypes and managing genetic resources in forest trees.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Local adaptation to climate facilitates a global invasion.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clément GainCentre National de la Recherche Scientifique, Université Grenoble-Alpes, Grenoble INP, TIMC UMR 5525, 38000 Grenoble, France.
Bénédicte RhonéDIADE, Université de Montpellier, Institut de Recherche pour le Développement, French Agricultural Research Centre for International Development (CIRAD), Montpellier, France.
Philippe CubryDIADE, Université de Montpellier, Institut de Recherche pour le Développement, French Agricultural Research Centre for International Development (CIRAD), Montpellier, France.
Israfel SalazarUniversité Grenoble-Alpes, Centre National de la Recherche Scientifique, Grenoble INP, Inria Grenoble - Rhône-Alpes, LJK UMR 5224, 655 Avenue de l'Europe, 38335 Montbonnot, France.
Florence ForbesUniversité Grenoble-Alpes, Centre National de la Recherche Scientifique, Grenoble INP, Inria Grenoble - Rhône-Alpes, LJK UMR 5224, 655 Avenue de l'Europe, 38335 Montbonnot, France.
Yves VigourouxDIADE, Université de Montpellier, Institut de Recherche pour le Développement, French Agricultural Research Centre for International Development (CIRAD), Montpellier, France.
Flora JayUniversité Paris-Saclay, Centre National de la Recherche Scientifique, Inria, Laboratoire Interdisciplinaire des Sciences du Numérique, UMR 9015, Orsay, France.ORCID 0000-0001-5884-4730
Olivier FrançoisCentre National de la Recherche Scientifique, Université Grenoble-Alpes, Grenoble INP, TIMC UMR 5525, 38000 Grenoble, France.ORCID 0000-0003-2402-2442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic offset statistics predict the maladaptation of populations to rapid habitat alteration based on association of genotypes with environmental variation. Despite substantial evidence for empirical validity, genomic offset statistics have well-identified limitations, and lack a theory that would facilitate interpretations of predicted values. Here, we clarified the theoretical relationships between genomic offset statistics and unobserved fitness traits controlled by environmentally selected loci and proposed a geometric measure to predict fitness after rapid change in local environment. The predictions of our theory were verified in computer simulations and in empirical data on African pearl millet (Cenchrus americanus) obtained from a common garden experiment. Our results proposed a unified perspective on genomic offset statistics and provided a theoretical foundation necessary when considering their potential application in conservation management in the face of environmental change.

Indexed as

PennisetumGenomicsGenotypePhenotypeclimate changegenomic offsetlocal adaptationpearl milletpredictive ecological genomics

Identifiers

PMID37307566
PMCPMC10306404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.