Evidence map›Paper›PMID 37307562›Full record

ArticleBiochemistry2023

SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism.

Janneke D Icso, Leonard Barasa, Paul R Thompson

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Subcellular NADNature metabolism · 2024
    Article
  2. Adaptation of a Commercial NADMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Janneke D IcsoProgram in Chemical Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, United States.
Leonard BarasaProgram in Chemical Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, United States.
Paul R ThompsonProgram in Chemical Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, United States.ORCID 0000-0002-1621-3372
University of Massachusetts Chan Medical School · US

Funding

Chemical probes to decipher PAD biologyR35GM118112 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Paul R Thompson · 2016 to 2026
$9.5M
Training in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6M
Investigating the Activation Mechanism of SARM1 during Axon DegenerationF31NS122423 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DOEDEE, JANNEKE · 2021 to 2023
$97k
NIAID NIH HHS T32 AI132152NIGMS NIH HHS R35 GM118112NINDS NIH HHS F31 NS122423
6 · The paper itself

Abstract

Sterile alpha and toll/interleukin receptor (TIR) motif containing protein 1 (SARM1) is an NAD

Indexed as

AxonsNADAnimalsCaenorhabditis elegansCatalytic DomainNAD

Identifiers

PMID37307562
PMCPMC10795796
OpenAlexW4380354242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.