ArticleProceedings of the National Academy of Sciences of the United States of America2023
Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses, and reduced fitness†.Biology of reproduction · 2026Article
- High-elevation adaptation and gestational hypoxia jointly shape vascular development in a rodent placenta.The Journal of physiology · 2025Article
- A physiological and histological atlas of reproduction in the North American deer mouse (Peromyscus maniculatus).PloS one · 2025Article
- Evolution of Litter Size: Proximate and Ultimate Mechanisms.Integrative and comparative biology · 2024Review
- To what extent do physiological tolerances determine elevational range limits of mammals?The Journal of physiology · 2024Article
- United by conflict: Convergent signatures of parental conflict in angiosperms and placental mammals.The Journal of heredity · 2024Review
- Placental-Heart Axis: An Evolutionary Perspective.International journal of molecular sciences · 2024Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Environmental hypoxia challenges female reproductive physiology in placental mammals, increasing rates of gestational complications. Adaptation to high elevation has limited many of these effects in humans and other mammals, offering potential insight into the developmental processes that lead to and protect against hypoxia-related gestational complications. However, our understanding of these adaptations has been hampered by a lack of experimental work linking the functional, regulatory, and genetic underpinnings of gestational development in locally adapted populations. Here, we dissect high-elevation adaptation in the reproductive physiology of deer mice (
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Registered trials
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