Evidence map›Paper›PMID 37307464›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.

Pooja Srinivas, Meisam Nosrati, Natalia Zelinskaya, Debayan Dey, Lindsay R Comstock, Christine M Dunham, Graeme L Conn

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  7. Review
  8. Mechanistic insights into 50Science advances · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. tRNA mbioRxiv : the preprint server for biology · 2023
    Article
  14. Antimicrobial resistance and mechanisms of epigenetic regulation.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pooja SrinivasDepartment of Chemistry, Emory University, Atlanta, GA 30322.ORCID 0000-0001-7796-8827
Meisam NosratiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Natalia ZelinskayaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-9387-051X
Debayan DeyDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Lindsay R ComstockDepartment of Chemistry, Wake Forest University, Winston-Salem, NC 27101.ORCID 0000-0003-0764-7344
Christine M DunhamDepartment of Chemistry, Emory University, Atlanta, GA 30322.ORCID 0000-0002-8821-688X
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-2419-380X
Emory University · USWake Forest University · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
RNA modification and antibiotic resistanceR01AI088025 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Christine M Dunham · 2010 to 2026
$7.9M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
NIAID NIH HHS R01 AI088025NIAID NIH HHS T32 AI106699NIGMS NIH HHS T32 GM008602NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the aminoglycoside-resistance 16S rRNA (m

Indexed as

AminoglycosidesAnti-Bacterial AgentsCryoelectron MicroscopyEscherichia coliMethyltransferasesRNA, RibosomalRNA, Ribosomal, 16SAminoglycosidesAnti-Bacterial AgentsMethyltransferasesRNA, RibosomalRNA, Ribosomal, 16Saminoglycoside resistancehelix 44methylationmethyltransferaseribosome

Identifiers

PMID37307464
PMCPMC10288597
OpenAlexW4380302619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.