Evidence map›Paper›PMID 37307347›Full record

Trial reportPsychological trauma : theory, research, practice and policy2024

An examination of the criterion-related validity of varying methods of indexing clinically significant change in posttraumatic stress disorder treatment.

Natasha Benfer, Benjamin C Darnell, Luke Rusowicz-Orazem, Elliot M Fielstein, Breanna Grunthal, Keren Lehavot, Brian P Marx, Brett Litz

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychological trauma : theory, research, practice and policy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natasha BenferMassachusetts Veterans Epidemiological Research and Information Center, VA Boston Healthcare System.ORCID 0000-0002-8179-5356
Benjamin C DarnellMassachusetts Veterans Epidemiological Research and Information Center, VA Boston Healthcare System.
Luke Rusowicz-OrazemMassachusetts Veterans Epidemiological Research and Information Center, VA Boston Healthcare System.
Elliot M FielsteinDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University.
Breanna GrunthalMassachusetts Veterans Epidemiological Research and Information Center, VA Boston Healthcare System.ORCID 0000-0001-7917-2558
Keren LehavotVA Puget Sound Health Care System.
Brian P MarxNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System.
Brett LitzMassachusetts Veterans Epidemiological Research and Information Center, VA Boston Healthcare System.

Funding

Evaluation of Web-Based CBT for Women Veterans with PTSDIK2CX000867 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI LEHAVOT, KEREN · 2014 to 2018
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CSRD VA IK2 CX000867US Department of Veterans Affairs; Clinical Science & Research Development (CSR&D)
6 · The paper itself

Abstract

objectiveClinicians, patients, and researchers need benchmarks to index individual-level clinically significant change (CSC) to guide decision making and inferences about treatment efficacy. Yet, there is no consensus best practice for determining CSC for posttraumatic stress disorder (PTSD) treatments. We examined criterion-related validity of the most common approach-Jacobson and Truax's (J&T; 1991) procedures for indexing CSC. We generated and compared four methods of calculating the J&T indices of CSC (two sets of sample-specific inputs, putatively norm-referenced benchmarks, and a combination of sample-specific and norm-referenced criteria) with respect to their association with a criterion index of quality of life (QoL).

methodParticipants were 91 women Veterans enrolled in a randomized clinical trial for PTSD who completed self-report measures on PTSD symptoms and various domains of QoL and functioning, pre- and posttreatment. For each of the four methods used to calculate CSC, the QoL composite was regressed onto the CSC categories.

resultsAll methods explained large variance in change in QoL. Across all methods, participants categorized as unchanged had smaller changes in QoL, compared with those who improved or had probable recovery. The norm-referenced benchmarks accounted for the relatively largest amount of variance in QoL, but categorized the fewest patients as having made CSC.

conclusionsThe J&T methodology for indexing CSC in PTSD symptoms has criterion-related validity, and a norm-referenced benchmark appears to be the most potent. However, the norm-referenced parameters may be overly specific, potentially leading to an underestimate of improvement. Research is needed to test the generalizability of these results. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Indexed as

Stress Disorders, Post-TraumaticVeteransAdultBenchmarkingFemaleHumansMiddle AgedOutcome Assessment, Health CareQuality of LifeReproducibility of Results

Identifiers

PMID37307347
PMCPMC10713857

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.