Evidence map›Paper›PMID 37306891›Full record

ArticleMolecular diversity2024

Synthesis of bis-thiohydantoin derivatives as an antiproliferative agents targeting EGFR inhibitory pathway.

Alaa A Hassan, Ashraf A Aly, Mohamed Ramadan, Nasr K Mohamed, Bahaa G M Youssif, Hesham A M Gomaa, Stefan Bräse, Martin Nieger, Amal S Abd El-Aal

Abstract read
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In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alaa A HassanChemistry Department, Faculty of Science, Organic Division, Minia University, El-Minia, 61519, Minia, Egypt. alaahassan2001@mu.edu.eg.
Ashraf A AlyChemistry Department, Faculty of Science, Organic Division, Minia University, El-Minia, 61519, Minia, Egypt.
Mohamed RamadanPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
Nasr K MohamedChemistry Department, Faculty of Science, Organic Division, Minia University, El-Minia, 61519, Minia, Egypt.
Bahaa G M YoussifPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. bahaa.youssif@pharm.aun.edu.eg.
Hesham A M GomaaDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, 72341, Aljouf, Saudi Arabia.
Stefan BräseInstitute of Organic Chemistry, Karlsruher Institut Fur Technologie, 76131, Karlsruhe, Germany.
Martin NiegerDepartment of Chemistry, University of Helsinki, A. I. Virtasen Aukio I, P.O. Box 55, 00014, Helsinki, Finland.
Amal S Abd El-AalChemistry Department, Faculty of Science, Organic Division, Minia University, El-Minia, 61519, Minia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(R)/(S)-the two enantiomers of 3-substituted-1-[2-(5)-3-substituted-4-benzyl-5-oxo-4-phenyl-2-thioxoimid-azolidin-1-yl]ethyl/propyl-5-benzyl-5-phenyl-2-thioxoimidazolidin-4-ones were formed during the diastereoselective reaction between N,N″-1,ω-alkanediylbis[N'-organylthiourea] derivatives and 2,3-diphenylcyclopropenone in refluxing ethanol. The structures of the isolated compounds were confirmed by NMR, IR, mass spectra and elemental analyses. Moreover, single-crystal X-ray structure analysis was also used to elucidate the structure of the isolated compounds. The mechanism describes the reaction was also discussed. The tested compounds showed EGFR inhibitory activity with IC

Indexed as

Antineoplastic AgentsCell ProliferationErbB ReceptorsMolecular Docking SimulationProtein Kinase InhibitorsThiohydantoinsCell Line, TumorHumansStructure-Activity RelationshipAntineoplastic AgentsEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsThiohydantoinsAntiproliferativeCyclopropenoneDockingEGFRHeterocycleThioureaThioxoimidazolidin-4-ones

Identifiers

PMID37306891

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.