Evidence map›Paper›PMID 37306825›Full record

ArticleSurgical case reports2023

Mixed neuroendocrine-non-neuroendocrine neoplasm of the ampulla of Vater: a case report.

Kenjiro Date, Takaaki Tatsuguchi, Yuzo Shimokawa, Yusuke Niina, Daichi Kitahara, Hirotaka Kuga, Sadafumi Tamiya, Kazuyoshi Nishihara, Toru Nakano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kenjiro DateDepartment of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, 802-8561, Japan. dateckham@gmail.com.ORCID http://orcid.org/0000-0003-0376-1000
Takaaki TatsuguchiDepartment of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, 802-8561, Japan.
Yuzo ShimokawaDepartment of Gastroenterology, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, Japan.
Yusuke NiinaDepartment of Gastroenterology, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, Japan.
Daichi KitaharaDepartment of Pathology, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, Japan.
Hirotaka KugaDepartment of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, 802-8561, Japan.
Sadafumi TamiyaDepartment of Pathology, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, Japan.
Kazuyoshi NishiharaDepartment of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, 802-8561, Japan.
Toru NakanoDepartment of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura Kita-Ku, Kitakyushu, Fukuoka, 802-8561, Japan.
Kitakyushu Municipal Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMixed neuroendocrine-non-neuroendocrine neoplasms of the ampulla of Vater are rare and heterogenous, making it difficult to achieve a definitive preoperative diagnosis. Herein, we describe a patient in whom a provisional diagnosis of mixed neuroendocrine-non-neuroendocrine neoplasm of the ampulla of Vater was made preoperatively. CASE PRESENTATION: Computed tomography revealed an enhancing periampullary tumor in a 69-year-old man with obstructive jaundice. Subsequent duodenoscopy revealed an ulcerated lesion in the swollen ampulla of Vater, from which six biopsies were collected. Pathological examination revealed adenocarcinoma in five of them. The remaining one was a neuroendocrine neoplasm according to immunohistochemical analysis. With a provisional diagnosis of mixed neuroendocrine-non-neuroendocrine neoplasm of the ampulla of Vater, the patient underwent subtotal stomach-preserving pancreaticoduodenectomy with modified Child's reconstruction and was discharged without complications. Pathological examination revealed both adenocarcinoma and neuroendocrine carcinomas, each accounting for ≥ 30% of the tumor, resulting in a definitive diagnosis of mixed neuroendocrine-non-neuroendocrine neoplasm of the ampulla of Vater. Lymph node metastases with neuroendocrine components were also observed. Adjuvant chemotherapy was not administered because of the patient's renal dysfunction. Liver and lymph node metastases were detected 2 months after surgery, the neuroendocrine component being considered responsible for that relapse. The patient underwent platinum-based chemotherapy at 50% dosage, which initially resulted in significant tumor shrinkage; however, he died 6 months after surgery.

conclusionsWhile these tumors' heterogeneity make definitive preoperative diagnosis of mixed neuroendocrine-non-neuroendocrine neoplasm of the ampulla of Vater difficult, the possibility of this disease can be considered by careful examination. Further study is needed to establish the optimal diagnostic criteria and treatment strategy.

Indexed as

AdenocarcinomaAmpulla of VaterMixed neuroendocrine–non-neuroendocrine neoplasmNeuroendocrine carcinoma

Identifiers

PMID37306825
PMCPMC10260704
OpenAlexW4380291963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.