Evidence map›Paper›PMID 37306741›Full record

ArticleHistochemistry and cell biology2023

Fetal growth at term and placental oxidative stress in a tissue micro-array model: a histological and immunohistochemistry study.

Serena Xodo, Lisa Celante, Stefania Liviero, Maria Orsaria, Laura Mariuzzi, Matteo De Luca, Giuseppe Damante, Lorenza Driul, Angelo Cagnacci, Annalisa Ferino and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histochemistry and cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. In focus in HCB.Histochemistry and cell biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Serena XodoClinic of Obstetrics and Gynecology, DAME, University of Udine, 33100, Udine, Italy. serena.xodo@gmail.com.
Lisa CelanteClinic of Obstetrics and Gynecology, DAME, University of Udine, 33100, Udine, Italy.
Stefania LivieroClinic of Obstetrics and Gynecology, DAME, University of Udine, 33100, Udine, Italy.
Maria OrsariaInstitute of Pathology, Academic Hospital "Azienda Sanitaria Universitaria Integrata di Udine", 33100, Udine, Italy.
Laura MariuzziInstitute of Pathology, DAME, University of Udine, 33100, Udine, Italy.
Matteo De LucaInstitute of Pathology, Academic Hospital "Azienda Sanitaria Universitaria Integrata di Udine", 33100, Udine, Italy.
Giuseppe DamanteInstitute of Medical Genetics, Academic Hospital "Azienda Sanitaria Universitaria Integrata di Udine", DAME, University of Udine, 33100, Udine, Italy.
Lorenza DriulClinic of Obstetrics and Gynecology, DAME, University of Udine, 33100, Udine, Italy.
Angelo CagnacciDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Infant Health, University of Genoa, Largo Rosanna Benzi 10, 16132, Genova, Italy.
Annalisa FerinoLaboratory of Biochemistry, Department of Medicine, University of Udine, 33100, Udine, Italy.
Eros Di GiorgioLaboratory of Biochemistry, Department of Medicine, University of Udine, 33100, Udine, Italy.
Luigi XodoLaboratory of Biochemistry, Department of Medicine, University of Udine, 33100, Udine, Italy.
Ambrogio Pietro LonderoDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Infant Health, University of Genoa, Largo Rosanna Benzi 10, 16132, Genova, Italy.
University of Udine · ITOspedale Santa Maria della Misericordia di Udine · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examines 8-hydroxyguanine (8-oxo-Gua) staining in placental tissue samples based on fetal size at birth as well as its relationships with placental histology and other pregnancy variables. This prospective cohort study included women > 18 years with a singleton pregnancy, a live fetus, fluency in Italian, and delivery at term. A total of 165 pregnancies were included in the study. The nuclear syncytiotrophoblast 8-oxo-Gua staining score in LGA was substantially greater than in late FGR (p < 0.05), although the cytoplasm score was lower in SGA and LGA than in AGA (p < 0.05). Furthermore, a sex-specific pattern of 8-oxo-Gua staining was discovered in single-term placentas, with more oxidative damage found in the nuclei of syncytiotrophoblast cells and stromal and endothelial cells in AGA males compared to AGA females (p < 0.05). Second, the histological pattern of late FGR placentae differed by gender. Finally, a significant correlation (p < 0.05) was found between high-intensity 8-oxo-Gua staining in the cytoplasm of syncytiotrophoblast cells and thrombi in the chorionic plate or villi in males. On the other hand, female fetuses demonstrated a significant connection (p < 0.05) between high-intensity 8-oxo-Gua staining in endothelial and stromal cells and high birthweight MoM values. Our findings indicated a significant variation in the oxidative stress pattern between male and female placentae, implying that fetal growth is regulated differently in the two sexes.

Indexed as

Endothelial CellsPlacentaFemaleFetal DevelopmentFetal Growth RetardationGestational AgeHumansImmunohistochemistryInfant, NewbornMalePregnancyProspective Studies8-Hydroxy-20deoxyguanosineFetal growthOxidative stressPlacentaPlacental histologySex-specific regulation

Identifiers

PMID37306741
PMCPMC10509069
OpenAlexW4380290772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.