Evidence map›Paper›PMID 37306720›Full record

Trial reportPediatric nephrology (Berlin, Germany)2023

Medication adherence in youths with CKD: habits for success.

Cyd K Eaton, Margaret Comer, Cozumel S Pruette, Kristin A Riekert

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03651596 (Leveraging mHealth Messaging to Promote Adherence in Teens With CKD), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03651596 nacompletednot on this map

Leveraging mHealth Messaging to Promote Adherence in Teens With CKD

TypeinterventionalSponsorJohns Hopkins UniversityRan2018 to 2020Enrolled35ConditionsChronic Kidney Diseases, Adherence, Medication, CommunicationArmsmHealth Messaging Intervention Group, Standard mHealth Messaging Group
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cyd K EatonJohns Hopkins University School of Medicine, 4200 Eastern Avenue, Baltimore, MD, 21224, USA. ceaton4@jhmi.edu.ORCID http://orcid.org/0000-0002-0908-1252
Margaret ComerJohns Hopkins University School of Medicine, 4200 Eastern Avenue, Baltimore, MD, 21224, USA.
Cozumel S PruetteJohns Hopkins University School of Medicine, 4200 Eastern Avenue, Baltimore, MD, 21224, USA.
Kristin A RiekertJohns Hopkins University School of Medicine, 4200 Eastern Avenue, Baltimore, MD, 21224, USA.

Funding

Leveraging mHealth Messaging to Promote Adherence, Capability, and Motivation in Teens with CKDF32DK118988 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI EATON, CYD KUMIKO · 2018 to 2019
$126k
NIDDK NIH HHS F32 DK118988
6 · The paper itself

Abstract

backgroundPoor adherence habits are key contributors to nonadherence but there are few clinically feasible methods for evaluating adherence habits, particularly for youths with chronic kidney disease (CKD). This study investigated how participants' qualitative responses to three interview questions about adherence habits mapped to primary principles of habit formation and objectively measured medication adherence in youths with CKD.

methodsParticipants (ages 11-21 years) were recruited from a pediatric nephrology clinic as part of a larger study. Participants' daily objective antihypertensive medication adherence was measured with an electronic pill bottle over a 4-week baseline period. Qualitative interviews about adherence habits and routines were conducted with a subset of participants (N = 18).

resultsClear qualitative differences emerged in how participants with high-medium adherence (80-100%) discussed adherence habits compared to participants with low adherence (0-79%). Participants with high-medium adherence discussed situational cues for taking medicine, including locations that cue adherence, step-by-step events leading up to taking medicine, and people who cue adherence. Participants with high-medium adherence regularly described taking medicine as "automatic," "second nature," and a "habit." Participants with low adherence rarely discussed these habit features nor did they explicitly acknowledge currently missing doses. Participants with low adherence tended to discuss challenges with organization and routines for taking medicine.

conclusionsEvaluating patient responses to questions about adherence habits may uncover challenges with adherence habit formation, provide direction for habit-strengthening intervention focused on developing automatic cues for taking medication, and support adherence successes for youths with CKD. CLINICAL TRIAL REGISTRATION NUMBER: NCT03651596. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Medication AdherenceRenal Insufficiency, ChronicAdolescentAntihypertensive AgentsChildHabitsHumansYoung AdultAntihypertensive AgentsChronic kidney diseaseHabitMedication nonadherence

Identifiers

PMID37306720
PMCPMC11587169

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.