ArticleJournal of the American Chemical Society2023
Characterization of Methyl- and Acetyl-Ni Intermediates in Acetyl CoA Synthase Formed during Anaerobic CO
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- In Vivo Enzyme Catalytic Rates in Formate-Growing Methanococcus maripaludis.Microbial biotechnology · 2026Article
- The mechanism of acetyl-CoA synthase through the lens of a nickel model system.Nature communications · 2025Article
- Conversion of pyridoxal to pyridoxamine with NHThe FEBS journal · 2025Article
- Ligand binding to a Ni-Fe cluster orchestrates conformational changes of the CO-dehydrogenase-acetyl-CoA synthase complex.Nature catalysis · 2025Article
- Capturing a methanogenic carbon monoxide dehydrogenase/acetyl-CoA synthase complex via cryogenic electron microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Chemical Antiquity in Metabolism.Accounts of chemical research · 2024Article
- Mixed Valence {NiJournal of the American Chemical Society · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The Wood-Ljungdahl Pathway is a unique biological mechanism of carbon dioxide and carbon monoxide fixation proposed to operate through nickel-based organometallic intermediates. The most unusual steps in this metabolic cycle involve a complex of two distinct nickel-iron-sulfur proteins: CO dehydrogenase and acetyl-CoA synthase (CODH/ACS). Here, we describe the nickel-methyl and nickel-acetyl intermediates in ACS completing the characterization of all its proposed organometallic intermediates. A single nickel site (Ni
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Registered trials
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