ArticleJournal of veterinary internal medicine
Red blood cell distribution width to platelet ratio in neonatal foals with sepsis.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Biomarkers of brain injury in foals with neonatal maladjustment syndrome.Journal of veterinary internal medicine · 2026Article
- Central nervous system lymphoma and neurolymphomatosis in equids.Journal of veterinary internal medicine · 2026Article
- Clinical applications of blood cell ratios in veterinary hematology: From diagnosis to prognosis.Veterinary and animal science · 2026Review
- Predicting sepsis prognosis using deep learning with routine biomarkers.Frontiers in medicine · 2026Article
- Red Cell Distribution Width to Red Blood Cell Ratio: A Novel Biomarker for Predicting 30-Day Mortality in Type B Acute Aortic Dissection.Emergency medicine international · 2026Article
- The predictive ability of blood-based biomarkers to detect bacteremia in hospitalized neonatal foals.Veterinary journal (London, England : 1997) · 2025Article
- Red Cell Distribution Width-to-Platelet Ratio and Other Hematological Markers as Early Predictors of Bronchopulmonary Dysplasia in Preterm Infants.Children (Basel, Switzerland) · 2025Article
- Hematologic Ratios in Donkeys: Reference Intervals and Response to Experimentally Induced Endotoxemia.Animals : an open access journal from MDPI · 2025Article
- An Overview of Donkey Neonatology.Animals : an open access journal from MDPI · 2025Review
- Evaluation of Blood Biochemical Parameters and Ratios in Piroplasmosis-Infected Horses in an Endemic Region.Veterinary sciences · 2025Article
- Assessment of Common Hematologic Parameters and Novel Hematologic Ratios for Predicting Piroplasmosis Infection in Horses.Animals : an open access journal from MDPI · 2025Article
- Diagnostic significance of complete blood cell count and hemogram-derived markers for neonatal sepsis at Southwest Public Hospitals, Ethiopia.World journal of clinical pediatrics · 2024Article
- The Systemic Inflammatory Response Syndrome and Predictors of Infection and Mortality in 1068 Critically Ill Newborn Foals.Journal of veterinary internal medicineArticle
- Red blood cell distribution width to platelet ratio in neonatal foals with sepsis.Journal of veterinary internal medicineArticle
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundRapid and accurate markers to aid diagnosis of sepsis are needed in neonatal foals. The CBC variable red blood cell distribution width (RDW) to platelet ratio (RPR) is associated with inflammatory response and linked to poor outcomes of sepsis in human patients. HYPOTHESIS: Explore the correlation of RPR with sepsis in neonatal foals and evaluate RPR predictive and prognostic value. ANIMALS: Three hundred seventeen hospitalized neonatal foals ≤7 days of age that had a CBC and physical exam performed at admission between 2012 and 2021.
methodsRetrospective case-control study. Clinical records were used to calculate sepsis scores and define groups. Red blood cell distribution width to platelet ratio was calculated and compared between groups (septic vs nonseptic) based on Kruskal-Wallis and Wilcoxon signed-rank tests. A multivariate logistic regression model to predict sepsis was created. The cutoff for RPR was obtained based on the maximal Youden Index. The Kaplan-Meier method and the log-rank test were used to estimate survival curves and compare survival rates based on RPR.
resultsRed blood cell distribution width to platelet ratio was significantly higher in septic foals (Median = 0.099, confidence interval [CI] [0.093; 0.108]) than in sick nonseptic (0.085, CI [0.083; 0.089]) and healthy foals (0.081, CI [0.077; 0.086]; P < .0001). Red blood cell distribution width to platelet ratio was able to predict sepsis with high accuracy (AUC = 82.1%). The optimal RPR cutoff for sepsis was 0.09. CONCLUSIONS AND CLINICAL IMPORTANCE: Red blood cell distribution width to platelet ratio calculation is practical, inexpensive, and based on CBC-derived data. Calculation of RPR along with CBC can aid in the diagnosis of sepsis and estimation of outcome.
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