ArticleHuman brain mapping2023
Network anatomy in logopenic variant of primary progressive aphasia.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Noninvasive Brain Stimulation in Primary Progressive Aphasia with and Without Concomitant Speech and Language Therapy: Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- A multi-modal approach for the treatment of non-fluent/agrammatic variant of Primary Progressive Aphasia.Brain communications · 2025Trial
- Beyond language: A structured profile of number processing impairment in logopenic primary progressive aphasia.Journal of Alzheimer's disease : JAD · 2026Article
- Multidimensional cognitive deficit in logopenic variant primary progressive aphasia: a case report.Journal of medical case reports · 2026Article
- Cognitive and brain reserve in bilingual speakers with clinical AD variants.medRxiv : the preprint server for health sciences · 2026Article
- Non-fluent agrammatic variant of primary progressive aphasia in a bilingual Mandarin/English speaker: a case report.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- The Diagnostic Role of FDG-PET in Dementias Presenting with Language and Behavioral Symptom.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Article
- Impairment of written word production in logopenic primary progressive aphasia: dissociating phonological and orthographic contributions.Frontiers in human neuroscience · 2026Article
- Artificial intelligence-based speech error detection to differentiate primary progressive aphasia variants.Brain communications · 2026Article
- Verbal learning in logopenic variant Primary Progressive Aphasia: An EEG investigation.Neurobiology of aging · 2026Article
- Data-driven neuroanatomical subtypes of primary progressive aphasia.Brain : a journal of neurology · 2025Article
- Effects of Cognitive Demand and Imaginability on Semantic Cognition in Patients with Primary Progressive Aphasia.Current Alzheimer research · 2025Article
- Effectiveness of a teletherapy-based phonological short-term memory training in reducing phonological impairments in the logopenic variant of primary progressive aphasia: a multiple case study.Frontiers in human neuroscience · 2025Article
- Impaired semantic control in the logopenic variant of primary progressive aphasia.Brain communications · 2025Article
- The Classification and Language Description of Patients with Primary Progressive Aphasia Using the Mini Linguistic State Examination Test.Geriatrics (Basel, Switzerland) · 2024Article
- Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Neuroanatomical correlates of language impairment in non-fluent variant of primary progressive aphasia.Frontiers in human neuroscience · 2024Article
- Network anatomy in logopenic variant of primary progressive aphasia.Human brain mapping · 2023Article
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Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
Abstract
The logopenic variant of primary progressive aphasia (lvPPA) is a neurodegenerative syndrome characterized linguistically by gradual loss of repetition and naming skills resulting from left posterior temporal and inferior parietal atrophy. Here, we sought to identify which specific cortical loci are initially targeted by the disease (epicenters) and investigate whether atrophy spreads through predetermined networks. First, we used cross-sectional structural MRI data from individuals with lvPPA to define putative disease epicenters using a surface-based approach paired with an anatomically fine-grained parcellation of the cortical surface (i.e., HCP-MMP1.0 atlas). Second, we combined cross-sectional functional MRI data from healthy controls and longitudinal structural MRI data from individuals with lvPPA to derive the epicenter-seeded resting-state networks most relevant to lvPPA symptomatology and ascertain whether functional connectivity in these networks predicts longitudinal atrophy spread in lvPPA. Our results show that two partially distinct brain networks anchored to the left anterior angular and posterior superior temporal gyri epicenters were preferentially associated with sentence repetition and naming skills in lvPPA. Critically, the strength of connectivity within these two networks in the neurologically-intact brain significantly predicted longitudinal atrophy progression in lvPPA. Taken together, our findings indicate that atrophy progression in lvPPA, starting from inferior parietal and temporoparietal junction regions, predominantly follows at least two partially nonoverlapping pathways, which may influence the heterogeneity in clinical presentation and prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.