ArticleCNS neuroscience & therapeutics2023
Functional connectomes of akinetic-rigid and tremor within drug-naïve Parkinson's disease.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Review
- Exploring biomechanical differences between brain-first and body-first Parkinson's disease subtypes using shear wave elastography: a pilot cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD.NPJ Parkinson's disease · 2025Article
- Understanding the role of cerebellum in early Parkinson's disease: a structural and functional MRI study.NPJ Parkinson's disease · 2024Article
- Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking.Brain sciences · 2024Article
- Functional connectomes of akinetic-rigid and tremor within drug-naïve Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo detect functional connectomes of akinetic-rigid (AR) and tremor and compare their connection pattern.
methodsResting-state functional MRI data of 78 drug-naïve PD patients were enrolled to construct connectomes of AR and tremor via connectome-based predictive modeling (CPM). The connectomes were further validated with 17 drug-naïve patients to verify their replication.
resultsThe connectomes related to AR and tremor were identified via CPM method and successfully validated in the independent set. Additional regional-based CPM demonstrated neither AR nor tremor could be simplified to functional changes within a single brain region. Computational lesion version of CPM revealed that parietal lobe and limbic system were the most important regions among AR-related connectome, and motor strip and cerebellum were the most important regions among tremor-related connectome. Comparing two connectomes found that the patterns of connection between them were largely distinct, with only four overlapped connections identified.
conclusionAR and tremor were found to be associated with functional changes in multiple brain regions. Distinct connection patterns of AR-related and tremor-related connectomes suggest different neural mechanisms underlying the two symptoms.
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