Evidence map›Paper›PMID 37305891›Full record

ArticleClinical case reports2023

Guillain-Barré syndrome following COVID-19 vaccination: An updated systematic review of cases.

Nour Shaheen, Abdelraouf Ramadan, Abdulqadir J Nashwan, Ahmed Shaheen, Shahzaib Ahmad, Karam R Motawea, Salaheldin Mohamed, Rahma Sameh Mohamed, Sarya Swed, Hani Aiash

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Nour ShaheenFaculty of Medicine Alexandria University Alexandria Egypt.ORCID https://orcid.org/0000-0001-8663-4044
Abdelraouf RamadanFaculty of Medicine Helwan University Cairo Egypt.
Abdulqadir J NashwanNursing Department Hamad Medical Corporation Doha Qatar.ORCID https://orcid.org/0000-0003-4845-4119
Ahmed ShaheenFaculty of Medicine Alexandria University Alexandria Egypt.
Shahzaib AhmadKing Edward Medical College: King Edward Medical University Lahore Pakistan.
Karam R MotaweaFaculty of Medicine Alexandria University Alexandria Egypt.
Salaheldin MohamedFaculty of Medicine Alexandria University Alexandria Egypt.
Rahma Sameh MohamedFaculty of Medicine Benha University Benha Egypt.
Sarya SwedFaculty of Medicine Aleppo University Aleppo Syria.ORCID https://orcid.org/0000-0002-9983-2020
Hani AiashCardiovascular Perfusion Department Upstate Medical University Syracuse New York USA.
Alexandria University · EGBenha University · EGHamad Medical Corporation · QAHelwan University · EGKing Edward Medical University · PKSUNY Upstate Medical University · USUniversity of Aleppo · SYUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Key Clinical Message: Guillain-Barré syndrome (GBS) is a rare but possible complication that may occur after COVID-19 vaccination. In this systematic review, we found that GBS presented in patients with an average age of 58. The average time for symptoms to appear was 14.4 days. Health care providers should be aware of this potential complication. Abstract: Most instances of Guillain-Barré syndrome (GBS) are caused by immunological stimulation and are discovered after vaccinations for tetanus toxoid, oral polio, and swine influenza. In this systematic study, we investigated at GBS cases that were reported after receiving the COVID-19 vaccination. Based on PRISMA guidelines, we searched five databases (PubMed, Google Scholar, Ovid, Web of Science, and Scopus databases) for studies on COVID-19 vaccination and GBS on August 7, 2021. To conduct our analysis, we divided the GBS variants into two groups, acute inflammatory demyelinating polyneuropathy and non-acute inflammatory demyelinating polyneuropathy (AIDP and non-AIDP), and compared the two groups with mEGOS and other clinical presentation In this systematic review, 29 cases were included in 14 studies. Ten cases belonged to the AIDP variant, 17 were non-AIDP (one case had the MFS variant, one AMAN variant, and 15 cases had the BFP variant), and the two remaining cases were not mentioned. Following COVID-19 vaccination, GBS cases were, on average, 58 years of age. The average time it took for GBS symptoms to appear was 14.4 days. About 56 percent of the cases (56%) were classified as Brighton Level 1 or 2, which defines the highest level of diagnostic certainty for patients with GBS. This systematic review reports 29 cases of GBS following COVID-19 vaccination, particularly those following the AstraZeneca/Oxford vaccine. Further research is needed to assess all COVID-19 vaccines' side effects, including GBS.

Indexed as

COVID‐19COVID‐19 vaccinesGuillain‐Barré syndrome (GBS)SARS‐CoV‐2

Identifiers

PMID37305891
PMCPMC10248205
OpenAlexW4380050101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.