Evidence map›Paper›PMID 37305850›Full record

ArticlebioRxiv : the preprint server for biology2023

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.

Hannah C Bennett, Qingguang Zhang, Yuan-Ting Wu, Uree Chon, Hyun-Jae Pi, Patrick J Drew, Yongsoo Kim

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hannah C BennettDepartment of Neural and Behavioral Sciences, The Pennsylvania State University, Hershey, PA, 17033, USA.
Qingguang ZhangCenter for Neural Engineering, Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Yuan-Ting WuDepartment of Neural and Behavioral Sciences, The Pennsylvania State University, Hershey, PA, 17033, USA.
Uree ChonDepartment of Neural and Behavioral Sciences, The Pennsylvania State University, Hershey, PA, 17033, USA.
Hyun-Jae PiDepartment of Neural and Behavioral Sciences, The Pennsylvania State University, Hershey, PA, 17033, USA.
Patrick J DrewCenter for Neural Engineering, Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Yongsoo KimDepartment of Neural and Behavioral Sciences, The Pennsylvania State University, Hershey, PA, 17033, USA.
Pennsylvania State University · US

Funding

Imaging neurovascular coupling and functional connectivity in the behaving mouseR01NS078168 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI DREW, PATRICK JAMES · 2013 to 2023
$3.3M
Understanding cellular architecture of the neurovascular unit and its function in the whole mouse brainR01NS108407 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIM, YONGSOO · 2018 to 2022
$3.1M
A multimodal approach to understanding the development of neurovascular couplingR01NS101353 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI DREW, PATRICK JAMES, ZHANG, NANYIN · 2017 to 2021
$2.2M
NINDS NIH HHS R01 NS078168NINDS NIH HHS R01 NS101353NINDS NIH HHS R01 NS108407
6 · The paper itself

Abstract

Aging is the largest risk factor for neurodegenerative disorders, and commonly associated with compromised cerebrovasculature and pericytes. However, we do not know how normal aging differentially impacts the vascular structure and function in different brain areas. Here we utilize mesoscale microscopy methods (serial two-photon tomography and light sheet microscopy) and

Indexed as

Agingbraincerebrovasculaturehigh-resolution mappinglight sheet fluorescence microscopyneurovascular couplingpericyteserial two-photon tomography

Identifiers

PMID37305850
PMCPMC10257218
OpenAlexW4378416722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.