Evidence map›Paper›PMID 37305841›Full record

ArticleOpen forum infectious diseases2023

Treatment of Piperacillin-Tazobactam-Nonsusceptible/Ceftriaxone-Susceptible Infections With Carbapenem Versus Carbapenem-Sparing Antimicrobials.

John Cao, Yanina Dubrovskaya, Justin Siegfried, Arnold Decano, Dana Mazo, Sarah Hochman, Ioannis M Zacharioudakis, Jonathan So, Sadie Solomon, John Papadopoulos and 1 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

John CaoDepartment of Pharmacy, NYU Langone Health, New York, New York, USA.
Yanina DubrovskayaDepartment of Pharmacy, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0002-0369-7072
Justin SiegfriedDepartment of Pharmacy, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0003-0492-4764
Arnold DecanoDepartment of Pharmacy, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0003-1763-0503
Dana MazoDivision of Infectious Diseases, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0002-9304-6563
Sarah HochmanDivision of Infectious Diseases, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0003-2011-0453
Ioannis M ZacharioudakisDivision of Infectious Diseases, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0002-7091-8437
Jonathan SoDepartment of Population Health, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0001-9919-2476
Sadie SolomonDepartment of Infection Prevention and Control, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0001-8358-9225
John PapadopoulosDepartment of Pharmacy, NYU Langone Health, New York, New York, USA.
Kassandra MarshDepartment of Pharmacy, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0002-6673-6091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: This was a retrospective study of noncritically ill adults hospitalized between 2013 and 2021 and treated at least 48 hours for TZP-NS/CRO-S Results: Of 1062 patients screened, 200 were included (CG, n = 51; CSG, n = 149). Baseline characteristics, including Charlson Comorbidity Index (CCI; median [interquartile range], 6 [3-9] vs 6 [4-9]; Conclusions: Our study did not find improved clinical outcomes with targeted carbapenem therapy for TZP-NS/CRO-S infections. Carbapenem-sparing agents may be considered to spare carbapenems in noncritically ill patients similar to those included in our cohort.

Indexed as

carbapenemscephalosporinsEscherichiaKlebsiellaβ-lactamases

Identifiers

PMID37305841
PMCPMC10249260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.