High-Risk Genotypes Associated with Poor Response to Controlled Ovarian Stimulation in Indian Women.

Background: Infertility is a global burden and has become exceedingly common in the preceding years; controlled ovarian stimulation (COS) is a pre-requisite for couples opting to conceive via Aims: This study aimed to establish a genomic basis for COS in IVF in the Indian population and to understand its predictive value. Settings and Design: The patient samples were collected at both Hegde Fertility Centre and GeneTech laboratory. The test was carried out at GeneTech, a diagnostic research laboratory based in Hyderabad, India. Patients with infertility without any history of polycystic ovary syndrome and hypogonadotropic hypogonadism were included in the study. Detailed clinical, medical and family history was obtained from patients. The controls had no history of secondary infertility or pregnancy losses. Materials and Methods: A total of 312 females were included in the study comprising 212 women with infertility and 100 controls. Next-generation sequencing technology was employed to sequence multiple genes associated with response to COS. Statistical Analysis Used: Statistical analysis using odds ratio was carried out to understand the significance of the results obtained. Results: Strong association of c.146G>T of Conclusion: This study has enabled the identification of potential markers pertaining to response to COS in the Indian population.