Evidence map›Paper›PMID 37305707›Full record

ArticleVirus evolution2023

Comparative whole genome analysis reveals re-emergence of human Wa-like and DS-1-like G3 rotaviruses after Rotarix vaccine introduction in Malawi.

Chimwemwe Mhango, Akuzike Banda, End Chinyama, Jonathan J Mandolo, Orpha Kumwenda, Chikondi Malamba-Banda, Kayla G Barnes, Benjamin Kumwenda, Kondwani C Jambo, Celeste M Donato and 11 more

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Complete genome sequence of aMicrobiology resource announcements · 2025
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 7 countries.

Chimwemwe MhangoMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.ORCID https://orcid.org/0000-0002-8769-7730
Akuzike BandaDepartment of Computer Science, Faculty of Science, University of Malawi, Zomba 305205, Malawi.
End ChinyamaMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Jonathan J MandoloMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Orpha KumwendaMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Chikondi Malamba-BandaMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Kayla G BarnesMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Benjamin KumwendaDepartment of Biomedical Sciences, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Kondwani C JamboMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Celeste M DonatoEnteric Diseases Group, Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Melbourne 3052, Australia.
Mathew D EsonaDiarrhoeal Pathogens Research Unit, Sefako Makgatho Health Sciences University, Medunsa, Pretoria 0204, South Africa.
Peter N MwangiNext Generation Sequencing Unit and Division of Virology, Faculty of Health Sciences, University of Free State, Bloemfontein 9300, South Africa.
A Duncan SteeleDiarrhoeal Pathogens Research Unit, Sefako Makgatho Health Sciences University, Medunsa, Pretoria 0204, South Africa.
Miren Iturriza-GomaraCentre for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Geneva 1218, Switzerland.
Nigel A CunliffeInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.
Valentine N NdzeFaculty of Health Sciences, University of Buea, PO Box 63, Buea, Cameroon.
Arox W Kamng'onaMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
Francis E DennisDepartment of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, P. O. Box LG 581, Legon, Ghana.
Martin M Nyaga
Chrispin ChaguzaInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.ORCID https://orcid.org/0000-0002-2108-1757
Khuzwayo C JereMalawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.
University of Liverpool · GBSefako Makgatho Health Sciences University · ZAUniversity of the Free State · ZAKamuzu Central Hospital · MWThe University of Melbourne · AUUniversity of Buea · CMUniversity of Ghana · GHUniversity of Malawi · MW

Funding

Wellcome Trust
6 · The paper itself

Abstract

G3 rotaviruses rank among the most common rotavirus strains worldwide in humans and animals. However, despite a robust long-term rotavirus surveillance system from 1997 at Queen Elizabeth Central Hospital in Blantyre, Malawi, these strains were only detected from 1997 to 1999 and then disappeared and re-emerged in 2017, 5 years after the introduction of the Rotarix rotavirus vaccine. Here, we analysed representative twenty-seven whole genome sequences (G3P[4],

Indexed as

G3 strainsgenotype re-emergenceimportationMalawiphylodynamicreassortmentRotarix vaccinerotavirussub-Saharan Africawhole genome sequencing

Identifiers

PMID37305707
PMCPMC10256189
OpenAlexW4377288878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.