Evidence map›Paper›PMID 37305679›Full record

ReviewFrontiers in cell and developmental biology2023

Antipsychotic-induced bone loss: the role of dopamine, serotonin and adrenergic receptor signalling.

D Kavindi Weerasinghe, Jason M Hodge, Julie A Pasco, Rasika M Samarasinghe, Behnaz Azimi Manavi, Lana J Williams

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07094568 (Comparative Investigation of Changes in Body Composition and Bone Turnover Markers in People With Obesity After Treatment With Tirzepatide Versus Liraglutide. A Prospective Cohort Study.), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07094568 recruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Investigation of Changes in Body Composition and Bone Turnover Markers in People With Obesity After Treatment With Tirzepatide Versus Liraglutide. A Prospective Cohort Study.

TypeobservationalSponsorNational and Kapodistrian University of AthensRan2025 to 2026Enrolled72ConditionsObesity (Disorder)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

D Kavindi WeerasingheIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Jason M HodgeIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Julie A PascoIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Rasika M SamarasingheIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Behnaz Azimi ManaviIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Lana J WilliamsIMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Deakin University · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antipsychotics are commonly used in treating psychiatric disorders. These medications primarily target dopamine the serotonin receptors, they have some affinity to adrenergic, histamine, glutamate and muscarinic receptors. There is clinical evidence that antipsychotic use decreases BMD and increases fracture risk, with dopamine, serotonin and adrenergic receptor-signalling becoming an increasing area of focus where the presence of these receptors in osteoclasts and osteoblasts have been demonstrated. Osteoclasts and osteoblasts are the most important cells in the bone remodelling and the bone regeneration process where the activity of these cells determine the bone resorption and formation process in order to maintain healthy bone. However, an imbalance in osteoclast and osteoblast activity can lead to decreased BMD and increased fracture risk, which is also believed to be exacerbated by antipsychotics use. Therefore, the aim of this review is to provide an overview of the mechanisms of action of first, second and third generation antipsychotics and the expression profiles of dopamine, serotonin and adrenergic receptors during osteoclastogenesis and osteoblastogenesis.

Indexed as

antipsychoticsbone mineral densitydopaminenoradrenalineosteoblastosteoclastschizophreniaserotonin

Identifiers

PMID37305679
PMCPMC10248006
OpenAlexW4378232948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.