Evidence map›Paper›PMID 37305558›Full record

ArticleHGG advances2023

Challenges in screening for

Christopher P Castro, Adam G Diehl, Alan P Boyle

Open access · goldAbstract read
In one paragraph

Article in HGG advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher P CastroDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Adam G DiehlDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Alan P BoyleDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · US

Funding

Training Program in BioinformaticsT32GM070449 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ATHEY, BRIAN DAVID, BURMEISTER, MARGIT · 2005 to 2020
$3.6M
RegulomeDB: A Resource for the Human RegulomeU24HG009293 · NHGRI · STANFORD UNIVERSITY · PI BOYLE, ALAN P, CHERRY, J. MICHAEL · 2020 to 2024
$3.3M
Resource Informatics and ProductionU41HG009293 · NHGRI · STANFORD UNIVERSITY · PI BOYLE, ALAN P · 2017 to 2019
$2.2M
NHGRI NIH HHS U24 HG009293NHGRI NIH HHS U41 HG009293NIGMS NIH HHS T32 GM070449
6 · The paper itself

Abstract

Understanding the genetic basis for complex, heterogeneous disorders, such as autism spectrum disorder (ASD), is a persistent challenge in human medicine. Owing to their phenotypic complexity, the genetic mechanisms underlying these disorders may be highly variable across individual patients. Furthermore, much of their heritability is unexplained by known regulatory or coding variants. Indeed, there is evidence that much of the causal genetic variation stems from rare and

Indexed as

Autism Spectrum DisorderMedicineCell MovementHumansPhenotypeReproducibility of Resultsautism geneticsde novo mutationnoncoding variation

Identifiers

PMID37305558
PMCPMC10248550
OpenAlexW4377138119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.