ReviewMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2023
Promising Schiff bases in antiviral drug design and discovery.
Review in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dynamic palladium catalysis enables chiral amplification toward acyclic Schiff base atropisomers.Nature communications · 2026Article
- Integrative design and optimization of bioactive schiff bases using computational intelligence and molecular modeling.Journal of computer-aided molecular design · 2026Article
- Synthesis, Computational Analysis, and Pharmacological Evaluation of Novel Schiff Base Hybrids for Anxiolytic and Skeletal Muscle-relaxant Activities.Central nervous system agents in medicinal chemistry · 2026Article
- Discovering the Cholinesterase Inhibitory Potential of Thiosemicarbazone Derivatives throughMedicinal chemistry (Shariqah (United Arab Emirates)) · 2026Article
- Novel thiophene-thiazole-Schiff base hybrids: design, synthesis, antimicrobial and antioxidant activity with ADMET prediction, molecular docking and dynamics study.RSC advances · 2025Article
- Design, synthesis, deep learning-guided prediction, and biological evaluation of novel pyridine-thiophene-based imine-benzalacetophenone hybrids as promising antimicrobial agent.Journal of computer-aided molecular design · 2025Article
- A Novel Rhodamine Functionalized Schiff Base Type Ratiometric Fluorescent Chemosensor for the Sensing of HgJournal of fluorescence · 2025Article
- Advances in Coordination Chemistry of Schiff Base Complexes: A Journey from Nanoarchitectonic Design to Biomedical Applications.Topics in current chemistry (Cham) · 2025Review
- Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents.Molecules (Basel, Switzerland) · 2025Review
- Imine Derivatives of Hydrochlorothiazide Bear Potential Diuretic Activity inCurrent medicinal chemistry · 2025Article
- Synthesis, crystal structure, and antiviral evaluation of new imidazopyridine-schiff base derivatives:RSC advances · 2024Article
- Synthesis and Biological Activity of New Hydrazones Based on N-Aminomorpholine.Molecules (Basel, Switzerland) · 2024Article
- Synthesis and Spectroscopic Characterization of Schiff Base Metal Complexes, Biological Activity, and Molecular Docking Studies.ACS omega · 2024Article
- Article
- Molecular docking, derivatization, characterization and biological assays of amantadine.Future medicinal chemistry · 2024Article
- The H2Valdien derivatives regulate the epithelial-mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway.Open medicine (Warsaw, Poland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging and re-emerging illnesses will probably present a new hazard of infectious diseases and have fostered the urge to research new antiviral agents. Most of the antiviral agents are analogs of nucleosides and only a few are non-nucleoside antiviral agents. There is quite a less percentage of marketed/clinically approved non-nucleoside antiviral medications. Schiff bases are organic compounds that possess a well-demonstrated profile against cancer, viruses, fungus, and bacteria, as well as in the management of diabetes, chemotherapy-resistant cases, and malarial infections. Schiff bases resemble aldehydes or ketones with an imine/azomethine group instead of a carbonyl ring. Schiff bases have a broad application profile not only in therapeutics/medicine but also in industrial applications. Researchers have synthesized and screened various Schiff base analogs for their antiviral potential. Some of the important heterocyclic compounds like istatin, thiosemicarbazide, quinazoline, quinoyl acetohydrazide, etc. have been used to derive novel Schiff base analogs. Keeping in view the outbreak of viral pandemics and epidemics, this manuscript compiles a review of Schiff base analogs concerning their antiviral properties and structural-activity relationship analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.