Evidence map›Paper›PMID 37305207›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2023

Design, synthesis, biochemical and in silico characterization of novel naphthalene-thiourea conjugates as potential and selective inhibitors of alkaline phosphatase.

Aamer Saeed, Saba Ashraf, Mubashir Aziz, Pervaiz Ali Channar, Syeda Abida Ejaz, Ammara Fayyaz, Qamar Abbas, Fatmah Ali Alasmary, Abdulnasser Mahmoud Karami, Arfa Tehzeeb and 2 more

Abstract read
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Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aamer SaeedDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320 Pakistan.ORCID 0000-0002-7112-9296
Saba AshrafDepartment of Chemistry, Rawalpindi Women University 6th Road, Satellite Town, Rawalpindi, Pakistan.
Mubashir AzizDepartment of Pharmaceutical Chemistry, Faculty of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Pakistan.
Pervaiz Ali ChannarDepartment of Basic sciences and Humanities, Faculty of Information Sciences and Humanities, Dawood University of Engineering and Technology, Karachi, 74800 Pakistan.
Syeda Abida EjazDepartment of Pharmaceutical Chemistry, Faculty of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Pakistan.ORCID 0000-0002-8516-7234
Ammara FayyazDepartment of Pharmaceutical Chemistry, Faculty of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Pakistan.
Qamar AbbasDepartment of Biology, College of Science, University of Bahrain, Sakhir, Kingdom of Bahrain.
Fatmah Ali AlasmaryDepartment of Chemistry, College of Science, King Saud University, Riyadh, 11451 Saudi Arabia.
Abdulnasser Mahmoud KaramiDepartment of Chemistry, College of Science, King Saud University, Riyadh, 11451 Saudi Arabia.
Arfa TehzeebDepartment of Pharmacy, Quaid-I-Azam University, 45320 Islamabad, Pakistan.
Amara MumtazDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060 Pakistan.
Hesham R El-SeediInternational Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naphthalene ring is present in a number of FDA-approved, commercially available medications, including naphyrone, terbinafine, propranolol, naproxen, duloxetine, lasofoxetine, and bedaquiline. By reacting newly obtained 1-naphthoyl isothiocyanate with properly modified anilines, a library of ten novel naphthalene-thiourea conjugates (

Indexed as

Alkaline phosphataseMolecular dockingNaphthoyl thioureasStructure-activity relationship

Identifiers

PMID37305207
PMCPMC10088808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.