Evidence map›Paper›PMID 37304758›Full record

ArticlePatterns (New York, N.Y.)2023

Evaluating vaccine allocation strategies using simulation-assisted causal modeling.

Armin Kekić, Jonas Dehning, Luigi Gresele, Julius von Kügelgen, Viola Priesemann, Bernhard Schölkopf

Open access · goldAbstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Armin KekićEmpirical Inference Department, Max Planck Institute for Intelligent Systems, 72076 Tübingen, Germany.
Jonas DehningMax Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Luigi GreseleEmpirical Inference Department, Max Planck Institute for Intelligent Systems, 72076 Tübingen, Germany.
Julius von KügelgenEmpirical Inference Department, Max Planck Institute for Intelligent Systems, 72076 Tübingen, Germany.
Viola PriesemannMax Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Bernhard SchölkopfEmpirical Inference Department, Max Planck Institute for Intelligent Systems, 72076 Tübingen, Germany.
Max Planck Institute for Intelligent Systems · DEMax Planck Institute for Dynamics and Self-Organization · DEUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We develop a model to retrospectively evaluate age-dependent counterfactual vaccine allocation strategies against the coronavirus disease 2019 (COVID-19) pandemic. To estimate the effect of allocation on the expected severe-case incidence, we employ a simulation-assisted causal modeling approach that combines a compartmental infection-dynamics simulation, a coarse-grained causal model, and literature estimates for immunity waning. We compare Israel's strategy, implemented in 2021, with counterfactual strategies such as no prioritization, prioritization of younger age groups, or a strict risk-ranked approach; we find that Israel's implemented strategy was indeed highly effective. We also study the impact of increasing vaccine uptake for given age groups. Because of its modular structure, our model can easily be adapted to study future pandemics. We demonstrate this by simulating a pandemic with characteristics of the Spanish flu. Our approach helps evaluate vaccination strategies under the complex interplay of core epidemic factors, including age-dependent risk profiles, immunity waning, vaccine availability, and spreading rates.

Indexed as

causalityCOVID-19modelingSEIR modelvaccinevaccine allocation

Identifiers

PMID37304758
PMCPMC10155501
OpenAlexW4367857414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.