ArticleNeurophotonics2023
Can pain under anesthesia be measured? Pain-related brain function using functional near-infrared spectroscopy during knee surgery.
Article in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Advancing pain assessment in Alzheimer's disease and related dementias: Functional near-infrared spectroscopy for investigating brain activity.British journal of pain · 2026Article
- Longitudinal patterns of postoperative brain oxygen saturation in children with congenital heart disease and postoperative delirium risk: a repeated measures analysis.Frontiers in pediatrics · 2026Article
- Interactive interdisciplinary pain research in adolescent and young adult females: a pilot investigation of brain, physiological, and emotional functioning following orthopedic surgery.Journal of pediatric psychology · 2025Article
- Barriers and facilitators for participation in brain magnetic resonance imaging (MRI) scans in cancer research: a feasibility and acceptability analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Somatosensory and prefrontal cortex activity relates to emotional outcomes and hair cortisol concentration in chronic postsurgical pain.Scientific reports · 2025Article
- Explainable fNIRS-based pain decoding under pharmacological conditions via deep transfer learning approach.Neurophotonics · 2024Article
- Machines, mathematics, and modules: the potential to provide real-time metrics for pain under anesthesia.Neurophotonics · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Significance: Quantitative measurement of perisurgical brain function may provide insights into the processes contributing to acute and chronic postsurgical pain. Aim: We evaluate the hemodynamic changes in the prefrontal cortex (medial frontopolar cortex/mFPC and lateral prefrontal cortex) and the primary somatosensory cortex/S1 using functional near-infrared spectroscopy (fNIRS) in 18 patients ( Approach: We examined the (a) hemodynamic response to surgery and (b) the relationship between surgery-modulated cortical connectivity (using beta-series correlation) and acute postoperative pain levels using Pearson's Results: We show a functional dissociation between mFPC and S1 in response to surgery, where mFPC deactivates, and S1 activates following a procedure. Furthermore, the connectivity between (a) left mFPC and right S1 (original Conclusions: Our findings suggest that greater functional dissociation between mFPC and S1 is likely the result of inadequately controlled nociceptive barrage during surgery leading to more significant postoperative pain. It also supports the utility of fNIRS during the perioperative state for pain monitoring and patient risk assessment for chronic pain.
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