Evidence map›Paper›PMID 37304666›Full record

ReviewFrontiers in neurorobotics2023

Lower extremity robotic exoskeleton devices for overground ambulation recovery in acquired brain injury-A review.

Kiran K Karunakaran, Sai D Pamula, Caitlyn P Bach, Eliana Legelen, Soha Saleh, Karen J Nolan

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in neurorobotics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07096700 (Virtual Reality for Gait Training in Multiple Sclerosis), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07096700 narecruitingnot on this mapstarted 2026, after this paper: background citation

Virtual Reality for Gait Training in Multiple Sclerosis (VIRTUE): an Interventional Feasibility Study

TypeinterventionalSponsorAzienda Usl di BolognaRan2026 to 2026Enrolled12ConditionsMultiple SclerosisArmsVR and walking brace-based gait rehabilitation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kiran K KarunakaranCenter for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United States.
Sai D PamulaCenter for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United States.
Caitlyn P BachCenter for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United States.
Eliana LegelenDepartment of Psychology, Montclair State University, Montclair, NJ, United States.
Soha SalehCenter for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United States.
Karen J NolanCenter for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United States.

Funding

Functional and neurophysiological effects of a progressive robot assisted gait intervention early post strokeR01HD099200 · NICHD · KESSLER FOUNDATION, INC. · PI NOLAN, KAREN J., SALEH, SOHA · 2019 to 2024
$3.5M
6 · The paper itself

Abstract

Acquired brain injury (ABI) is a leading cause of ambulation deficits in the United States every year. ABI (stroke, traumatic brain injury and cerebral palsy) results in ambulation deficits with residual gait and balance deviations persisting even after 1 year. Current research is focused on evaluating the effect of robotic exoskeleton devices (RD) for overground gait and balance training. In order to understand the device effectiveness on neuroplasticity, it is important to understand RD effectiveness in the context of both downstream (functional, biomechanical and physiological) and upstream (cortical) metrics. The review identifies gaps in research areas and suggests recommendations for future research. We carefully delineate between the preliminary studies and randomized clinical trials in the interpretation of existing evidence. We present a comprehensive review of the clinical and pre-clinical research that evaluated therapeutic effects of RDs using various domains, diagnosis and stage of recovery.

Indexed as

balancecerebral palsygaitrehabilitationrobotic exoskeletonstroketraumatic brain injury

Identifiers

PMID37304666
PMCPMC10249611

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.