ArticleFrontiers in psychiatry2023
A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Rewiring reward in addiction: a systematic review of human evidence for deep brain stimulation and lesion approaches in substance use disorders.Acta neurochirurgica · 2026Pooled it
- Comparison of the Treatments in Crack Use Disorder: A Systematic Review.European addiction research · 2026Pooled it
- A systematic review of deep brain stimulation for substance use disorders.Translational psychiatry · 2024Pooled it
- Deep Brain Stimulation in Treatment-Resistant Psychiatric Disorders: Efficacy, Safety, and Future Directions.Brain sciences · 2025Review
- Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Zona incerta: from Parkinson's disease to addiction.Frontiers in neural circuits · 2025Article
- Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI.Molecular psychiatry · 2024Article
- Deep brain stimulation for psychostimulant use disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the effects of STN-DBS on cocaine craving and cocaine use, as well as STN-DBS safety and tolerance in this indication. In this pilot study, we performed double blind cross-over trials, with "ON-DBS" vs. "SHAM-DBS" for 1-month periods. STN-DBS failed to reduce cocaine craving and use. An episode of DBS-induced hypomania occurred after several weeks of cocaine intake at stimulation parameters previously well tolerated. Future research on cocaine dependence should be conducted after a prolonged abstinence period and/or explore novel types of stimulation patterns.
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