Evidence map›Paper›PMID 37304388›Full record

ReviewCureus2023

An Integrated Review of Carpal Tunnel Syndrome: New Insights to an Old Problem.

Adekunle E Omole, Ayoola Awosika, Anosh Khan, Uzochukwu Adabanya, Nikhilesh Anand, Tirath Patel, Carolyn K Edmondson, Adegbenro O Fakoya, Richard M Millis

Open access · diamondAbstract readReview
In one paragraph

Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Adekunle E OmoleAnatomical Sciences, American University of Antigua, Saint John, ATG.
Ayoola AwosikaCollege of Medicine, University of Illinois, Chicago, USA.
Anosh KhanEmergency Medicine, Spartan Health Sciences University, Vieux Fort, LCA.
Uzochukwu AdabanyaCommunity Medicine, Mercer University School of Medicine, Columbus, USA.
Nikhilesh AnandPharmacology, American University of Antigua, Saint John, ATG.
Tirath PatelSurgery, American University of Antigua, Saint John, ATG.
Carolyn K EdmondsonClinical Medicine, American University of Antigua, Saint John, ATG.
Adegbenro O FakoyaCellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA.
Richard M MillisPathophysiology, American University of Antigua, Saint John, ATG.
Mercer (Czechia) · CZLouisiana State University Health Sciences Center Shreveport · USUniversity of Illinois Chicago · USIllinois College · USMercer University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carpal tunnel syndrome (CTS) is a common entrapment neuropathy characterized by pain, numbness, and impaired function of the hand due to compression of the median nerve at the level of the wrist. Although CTS can develop from repetitive strain, injury, or medical conditions, there are also congenital and genetic risk factors that can predispose individuals to the condition. With respect to anatomical factors, some individuals are born with a smaller carpal tunnel, which increases their susceptibility to median nerve compression. Variations in specific genes, such as those encoding proteins involved in extracellular matrix remodeling, inflammation, and nerve function, have also been linked to an increased risk for CTS. CTS is associated with a high cost of health care maintenance and loss of work productivity. Therefore, it is vital that primary care physicians fully understand the anatomy, epidemiology, pathophysiology, etiology, and risk factors of CTS, so they can be proactive in prevention, diagnosing, and guiding proper treatment. This integrated review also provides insights into how biological, genetic, environmental, and occupational factors interact with structural elements to determine who is most likely to acquire and suffer from CTS. Keeping health practitioners abreast of all the factors that could impact CTS should go a long way in decreasing the health care and socioeconomic burden of CTS.

Indexed as

carpal tunnelcarpal tunnel syndromemedian nervenerve entrapmentneuropathy

Identifiers

PMID37304388
PMCPMC10250024
OpenAlexW4379928018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.