Evidence map›Paper›PMID 37304269›Full record

SynthesisFrontiers in immunology2023

Genetic bases of C7 deficiency: systematic review and report of a novel deletion determining functional hemizygosity.

Andrea Balduit, Anna Monica Bianco, Alessandro Mangogna, Anna Maria Zicari, Lucia Leonardi, Bianca Laura Cinicola, Martina Capponi, Alberto Tommasini, Chiara Agostinis, Adamo Pio d'Adamo and 1 more

Open access · goldAbstract readCase ReportsSystematic Review
In one paragraph

Synthesis in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. The 'autoimmunome' of centenarians.Journal of translational autoimmunity · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andrea BalduitInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Anna Monica BiancoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Alessandro MangognaInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Anna Maria ZicariDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Lucia LeonardiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Bianca Laura CinicolaDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Martina CapponiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Alberto TommasiniInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Chiara AgostinisInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Adamo Pio d'AdamoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Roberta BullaDepartment of Life Sciences, University of Trieste, Trieste, Italy.
IRCCS Materno Infantile Burlo Garofolo · ITSapienza University of Rome · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary complement system (C) deficiencies are rare but notably associated with an increased risk of infections, autoimmunity, or immune disorders. Patients with terminal pathway C-deficiency have a 1,000- to 10,000-fold-higher risk of

Indexed as

AutoimmunityBiological Assay3' Untranslated RegionsAllelesChildComplement C7Hereditary Complement Deficiency DiseasesHumansMale3' Untranslated RegionsComplement C7complement component 7 (C7)complement deficiencycomplement systemfunctional hemizygosityprimary immunodeficiency

Identifiers

PMID37304269
PMCPMC10248053
OpenAlexW4378232713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.